Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART

HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Mens, Helene, Fjordside, Lasse, Fonager, Jannik, Gerstoft, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326666/
https://www.ncbi.nlm.nih.gov/pubmed/35893472
http://dx.doi.org/10.3390/idr14040053
_version_ 1784757341118267392
author Mens, Helene
Fjordside, Lasse
Fonager, Jannik
Gerstoft, Jan
author_facet Mens, Helene
Fjordside, Lasse
Fonager, Jannik
Gerstoft, Jan
author_sort Mens, Helene
collection PubMed
description HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.
format Online
Article
Text
id pubmed-9326666
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93266662022-07-28 Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART Mens, Helene Fjordside, Lasse Fonager, Jannik Gerstoft, Jan Infect Dis Rep Communication HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies. MDPI 2022-06-22 /pmc/articles/PMC9326666/ /pubmed/35893472 http://dx.doi.org/10.3390/idr14040053 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Mens, Helene
Fjordside, Lasse
Fonager, Jannik
Gerstoft, Jan
Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
title Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
title_full Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
title_fullStr Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
title_full_unstemmed Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
title_short Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
title_sort emergence of the g118r pan-integrase resistance mutation as a result of low compliance to a dolutegravir-based cart
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326666/
https://www.ncbi.nlm.nih.gov/pubmed/35893472
http://dx.doi.org/10.3390/idr14040053
work_keys_str_mv AT menshelene emergenceoftheg118rpanintegraseresistancemutationasaresultoflowcompliancetoadolutegravirbasedcart
AT fjordsidelasse emergenceoftheg118rpanintegraseresistancemutationasaresultoflowcompliancetoadolutegravirbasedcart
AT fonagerjannik emergenceoftheg118rpanintegraseresistancemutationasaresultoflowcompliancetoadolutegravirbasedcart
AT gerstoftjan emergenceoftheg118rpanintegraseresistancemutationasaresultoflowcompliancetoadolutegravirbasedcart

Ejemplares similares