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Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

INTRODUCTION: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP). MATERIAL AND METHODS: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018...

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Autores principales: Philippi, Alexander, Mandel, Philipp, Hohenhorst, Jan L., Wenzel, Mike, Humke, Clara, Wittler, Clarissa, Köllermann, Jens, Steuber, Thomas, Graefen, Markus, Tilki, Derya, Karakiewicz, Pierre I., Preisser, Felix, Becker, Andreas, Kluth, Luis A., Chun, Felix K.H., Hoeh, Benedikt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Urological Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326700/
https://www.ncbi.nlm.nih.gov/pubmed/35937658
http://dx.doi.org/10.5173/ceju.2022.0279.R1
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author Philippi, Alexander
Mandel, Philipp
Hohenhorst, Jan L.
Wenzel, Mike
Humke, Clara
Wittler, Clarissa
Köllermann, Jens
Steuber, Thomas
Graefen, Markus
Tilki, Derya
Karakiewicz, Pierre I.
Preisser, Felix
Becker, Andreas
Kluth, Luis A.
Chun, Felix K.H.
Hoeh, Benedikt
author_facet Philippi, Alexander
Mandel, Philipp
Hohenhorst, Jan L.
Wenzel, Mike
Humke, Clara
Wittler, Clarissa
Köllermann, Jens
Steuber, Thomas
Graefen, Markus
Tilki, Derya
Karakiewicz, Pierre I.
Preisser, Felix
Becker, Andreas
Kluth, Luis A.
Chun, Felix K.H.
Hoeh, Benedikt
author_sort Philippi, Alexander
collection PubMed
description INTRODUCTION: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP). MATERIAL AND METHODS: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30–90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours. Univariable and multivariable logistic regression models tested the correlation between DM and short-term continence. Covariates consisted of pathological T-stage, body mass index, prostate volume, surgical approach and nerve-sparing. RESULTS: Of 142 eligible patients, 15 (11%) patients exhibited concomitant DM. Patients diagnosed with DM exhibited lower continence rates at short-term follow-up compared to patients without DM (33 vs 63%, p = 0.03). In univariable and multivariable logistic regression models, DM was strongly associated with reduced chances of short-term urinary continence recovery (multivariable odds ratio [OR]: 0.26, 95%-CI: 0.07–0.86; p = 0.03). Furthermore, pathological T-stage (pT3/pT4) was additionally associated with reduced chance of urinary continence in logistic regression models (multivariable OR: 0.43, 95%-CI: 0.19–0.94; p = 0.04). Other covariables failed to reach statistical significance in multivariable logistic regression analyses predicting urinary continence. CONCLUSIONS: DM was associated with lower chances of short-term urinary continence recovery in a contemporary cohort of patients undergoing radical prostatectomy. Patients with DM should be preoperatively informed and intensified, postoperative pelvic floor training should be considered in this subgroup of RP patients.
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spelling pubmed-93267002022-08-04 Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy Philippi, Alexander Mandel, Philipp Hohenhorst, Jan L. Wenzel, Mike Humke, Clara Wittler, Clarissa Köllermann, Jens Steuber, Thomas Graefen, Markus Tilki, Derya Karakiewicz, Pierre I. Preisser, Felix Becker, Andreas Kluth, Luis A. Chun, Felix K.H. Hoeh, Benedikt Cent European J Urol Original Paper INTRODUCTION: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP). MATERIAL AND METHODS: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30–90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours. Univariable and multivariable logistic regression models tested the correlation between DM and short-term continence. Covariates consisted of pathological T-stage, body mass index, prostate volume, surgical approach and nerve-sparing. RESULTS: Of 142 eligible patients, 15 (11%) patients exhibited concomitant DM. Patients diagnosed with DM exhibited lower continence rates at short-term follow-up compared to patients without DM (33 vs 63%, p = 0.03). In univariable and multivariable logistic regression models, DM was strongly associated with reduced chances of short-term urinary continence recovery (multivariable odds ratio [OR]: 0.26, 95%-CI: 0.07–0.86; p = 0.03). Furthermore, pathological T-stage (pT3/pT4) was additionally associated with reduced chance of urinary continence in logistic regression models (multivariable OR: 0.43, 95%-CI: 0.19–0.94; p = 0.04). Other covariables failed to reach statistical significance in multivariable logistic regression analyses predicting urinary continence. CONCLUSIONS: DM was associated with lower chances of short-term urinary continence recovery in a contemporary cohort of patients undergoing radical prostatectomy. Patients with DM should be preoperatively informed and intensified, postoperative pelvic floor training should be considered in this subgroup of RP patients. Polish Urological Association 2022-06-04 2022 /pmc/articles/PMC9326700/ /pubmed/35937658 http://dx.doi.org/10.5173/ceju.2022.0279.R1 Text en Copyright by Polish Urological Association https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Philippi, Alexander
Mandel, Philipp
Hohenhorst, Jan L.
Wenzel, Mike
Humke, Clara
Wittler, Clarissa
Köllermann, Jens
Steuber, Thomas
Graefen, Markus
Tilki, Derya
Karakiewicz, Pierre I.
Preisser, Felix
Becker, Andreas
Kluth, Luis A.
Chun, Felix K.H.
Hoeh, Benedikt
Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
title Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
title_full Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
title_fullStr Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
title_full_unstemmed Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
title_short Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
title_sort diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326700/
https://www.ncbi.nlm.nih.gov/pubmed/35937658
http://dx.doi.org/10.5173/ceju.2022.0279.R1
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