The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326733/ https://www.ncbi.nlm.nih.gov/pubmed/35892480 http://dx.doi.org/10.3390/dermatopathology9030027 |
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author | Pendlebury, Gehan A. Oro, Peter Haynes, William Merideth, Drew Bartling, Samantha Bongiorno, Michelle A. |
author_facet | Pendlebury, Gehan A. Oro, Peter Haynes, William Merideth, Drew Bartling, Samantha Bongiorno, Michelle A. |
author_sort | Pendlebury, Gehan A. |
collection | PubMed |
description | Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of dermatological manifestations associated with the Coronavirus Disease 2019 (COVID-19) pandemic. To date, this literature review is the first broad-spectrum examination that analyzes a range of dermatological manifestations related to the COVID-19 pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Methods: A detailed literature search was conducted using key terms for cutaneous manifestations associated with the scope of this review. The search retrieved 2199 articles. Results: The COVID-19 pandemic has triggered a significant range of dermatologic sequela. Etiologies of lesions continue to be investigated. Proposed mechanisms include inflammatory response to spike protein, vitamin D deficiency, ACE2 receptor activation, androgen levels, and increased psychological stress. One prominent mechanism describes viral spike protein invasion into the dermis by binding to the angiotensin-converting enzyme 2 (ACE-2) receptors in keratinocytes, with a secondary immunological response. Conclusions: Dermatologists play an integral role in the proper diagnosis and treatment of COVID-related lesions. Early treatment regimens and timely prophylaxis have been shown to safely reduce infection-related dermatological sequelae. Additional investigations and data collection can reduce disease burden and improve overall prognosis. |
format | Online Article Text |
id | pubmed-9326733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93267332022-07-28 The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review Pendlebury, Gehan A. Oro, Peter Haynes, William Merideth, Drew Bartling, Samantha Bongiorno, Michelle A. Dermatopathology (Basel) Review Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of dermatological manifestations associated with the Coronavirus Disease 2019 (COVID-19) pandemic. To date, this literature review is the first broad-spectrum examination that analyzes a range of dermatological manifestations related to the COVID-19 pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Methods: A detailed literature search was conducted using key terms for cutaneous manifestations associated with the scope of this review. The search retrieved 2199 articles. Results: The COVID-19 pandemic has triggered a significant range of dermatologic sequela. Etiologies of lesions continue to be investigated. Proposed mechanisms include inflammatory response to spike protein, vitamin D deficiency, ACE2 receptor activation, androgen levels, and increased psychological stress. One prominent mechanism describes viral spike protein invasion into the dermis by binding to the angiotensin-converting enzyme 2 (ACE-2) receptors in keratinocytes, with a secondary immunological response. Conclusions: Dermatologists play an integral role in the proper diagnosis and treatment of COVID-related lesions. Early treatment regimens and timely prophylaxis have been shown to safely reduce infection-related dermatological sequelae. Additional investigations and data collection can reduce disease burden and improve overall prognosis. MDPI 2022-06-29 /pmc/articles/PMC9326733/ /pubmed/35892480 http://dx.doi.org/10.3390/dermatopathology9030027 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pendlebury, Gehan A. Oro, Peter Haynes, William Merideth, Drew Bartling, Samantha Bongiorno, Michelle A. The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review |
title | The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review |
title_full | The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review |
title_fullStr | The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review |
title_full_unstemmed | The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review |
title_short | The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review |
title_sort | impact of covid-19 pandemic on dermatological conditions: a novel, comprehensive review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326733/ https://www.ncbi.nlm.nih.gov/pubmed/35892480 http://dx.doi.org/10.3390/dermatopathology9030027 |
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