The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review

Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of...

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Autores principales: Pendlebury, Gehan A., Oro, Peter, Haynes, William, Merideth, Drew, Bartling, Samantha, Bongiorno, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326733/
https://www.ncbi.nlm.nih.gov/pubmed/35892480
http://dx.doi.org/10.3390/dermatopathology9030027
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author Pendlebury, Gehan A.
Oro, Peter
Haynes, William
Merideth, Drew
Bartling, Samantha
Bongiorno, Michelle A.
author_facet Pendlebury, Gehan A.
Oro, Peter
Haynes, William
Merideth, Drew
Bartling, Samantha
Bongiorno, Michelle A.
author_sort Pendlebury, Gehan A.
collection PubMed
description Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of dermatological manifestations associated with the Coronavirus Disease 2019 (COVID-19) pandemic. To date, this literature review is the first broad-spectrum examination that analyzes a range of dermatological manifestations related to the COVID-19 pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Methods: A detailed literature search was conducted using key terms for cutaneous manifestations associated with the scope of this review. The search retrieved 2199 articles. Results: The COVID-19 pandemic has triggered a significant range of dermatologic sequela. Etiologies of lesions continue to be investigated. Proposed mechanisms include inflammatory response to spike protein, vitamin D deficiency, ACE2 receptor activation, androgen levels, and increased psychological stress. One prominent mechanism describes viral spike protein invasion into the dermis by binding to the angiotensin-converting enzyme 2 (ACE-2) receptors in keratinocytes, with a secondary immunological response. Conclusions: Dermatologists play an integral role in the proper diagnosis and treatment of COVID-related lesions. Early treatment regimens and timely prophylaxis have been shown to safely reduce infection-related dermatological sequelae. Additional investigations and data collection can reduce disease burden and improve overall prognosis.
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spelling pubmed-93267332022-07-28 The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review Pendlebury, Gehan A. Oro, Peter Haynes, William Merideth, Drew Bartling, Samantha Bongiorno, Michelle A. Dermatopathology (Basel) Review Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of dermatological manifestations associated with the Coronavirus Disease 2019 (COVID-19) pandemic. To date, this literature review is the first broad-spectrum examination that analyzes a range of dermatological manifestations related to the COVID-19 pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Methods: A detailed literature search was conducted using key terms for cutaneous manifestations associated with the scope of this review. The search retrieved 2199 articles. Results: The COVID-19 pandemic has triggered a significant range of dermatologic sequela. Etiologies of lesions continue to be investigated. Proposed mechanisms include inflammatory response to spike protein, vitamin D deficiency, ACE2 receptor activation, androgen levels, and increased psychological stress. One prominent mechanism describes viral spike protein invasion into the dermis by binding to the angiotensin-converting enzyme 2 (ACE-2) receptors in keratinocytes, with a secondary immunological response. Conclusions: Dermatologists play an integral role in the proper diagnosis and treatment of COVID-related lesions. Early treatment regimens and timely prophylaxis have been shown to safely reduce infection-related dermatological sequelae. Additional investigations and data collection can reduce disease burden and improve overall prognosis. MDPI 2022-06-29 /pmc/articles/PMC9326733/ /pubmed/35892480 http://dx.doi.org/10.3390/dermatopathology9030027 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pendlebury, Gehan A.
Oro, Peter
Haynes, William
Merideth, Drew
Bartling, Samantha
Bongiorno, Michelle A.
The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
title The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
title_full The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
title_fullStr The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
title_full_unstemmed The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
title_short The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
title_sort impact of covid-19 pandemic on dermatological conditions: a novel, comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326733/
https://www.ncbi.nlm.nih.gov/pubmed/35892480
http://dx.doi.org/10.3390/dermatopathology9030027
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