Association between Empagliflozin Use and Electrocardiographic Changes

Empagliflozin, a sodium-glucose transporter 2 inhibitor, has been shown to bind to late sodium channels in mice cardiomyocytes. We sought to investigate the electrocardiographic (ECG) features associated with empagliflozin use in patients with diabetes mellitus. We compared ECG features of 101 patie...

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Autores principales: Antwi-Amoabeng, Daniel, Sathappan, Sunil, Beutler, Bryce D., Ulanja, Mark B., Awad, Munadel, Gullapalli, Nageshwara, Duncan, Phillip, Gbadebo, T. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326746/
https://www.ncbi.nlm.nih.gov/pubmed/35892445
http://dx.doi.org/10.3390/clinpract12040059
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author Antwi-Amoabeng, Daniel
Sathappan, Sunil
Beutler, Bryce D.
Ulanja, Mark B.
Awad, Munadel
Gullapalli, Nageshwara
Duncan, Phillip
Gbadebo, T. David
author_facet Antwi-Amoabeng, Daniel
Sathappan, Sunil
Beutler, Bryce D.
Ulanja, Mark B.
Awad, Munadel
Gullapalli, Nageshwara
Duncan, Phillip
Gbadebo, T. David
author_sort Antwi-Amoabeng, Daniel
collection PubMed
description Empagliflozin, a sodium-glucose transporter 2 inhibitor, has been shown to bind to late sodium channels in mice cardiomyocytes. We sought to investigate the electrocardiographic (ECG) features associated with empagliflozin use in patients with diabetes mellitus. We compared ECG features of 101 patients before and after initiation of empagliflozin and found that empagliflozin was associated with a significant increase in QRS duration among diabetes patients with heart failure.
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spelling pubmed-93267462022-07-28 Association between Empagliflozin Use and Electrocardiographic Changes Antwi-Amoabeng, Daniel Sathappan, Sunil Beutler, Bryce D. Ulanja, Mark B. Awad, Munadel Gullapalli, Nageshwara Duncan, Phillip Gbadebo, T. David Clin Pract Article Empagliflozin, a sodium-glucose transporter 2 inhibitor, has been shown to bind to late sodium channels in mice cardiomyocytes. We sought to investigate the electrocardiographic (ECG) features associated with empagliflozin use in patients with diabetes mellitus. We compared ECG features of 101 patients before and after initiation of empagliflozin and found that empagliflozin was associated with a significant increase in QRS duration among diabetes patients with heart failure. MDPI 2022-07-15 /pmc/articles/PMC9326746/ /pubmed/35892445 http://dx.doi.org/10.3390/clinpract12040059 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Antwi-Amoabeng, Daniel
Sathappan, Sunil
Beutler, Bryce D.
Ulanja, Mark B.
Awad, Munadel
Gullapalli, Nageshwara
Duncan, Phillip
Gbadebo, T. David
Association between Empagliflozin Use and Electrocardiographic Changes
title Association between Empagliflozin Use and Electrocardiographic Changes
title_full Association between Empagliflozin Use and Electrocardiographic Changes
title_fullStr Association between Empagliflozin Use and Electrocardiographic Changes
title_full_unstemmed Association between Empagliflozin Use and Electrocardiographic Changes
title_short Association between Empagliflozin Use and Electrocardiographic Changes
title_sort association between empagliflozin use and electrocardiographic changes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326746/
https://www.ncbi.nlm.nih.gov/pubmed/35892445
http://dx.doi.org/10.3390/clinpract12040059
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