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Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increas...

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Autores principales: Cao, Huiliang, Qiao, Shichong, Qin, Hui, Jandt, Klaus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326756/
https://www.ncbi.nlm.nih.gov/pubmed/35893454
http://dx.doi.org/10.3390/jfb13030086
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author Cao, Huiliang
Qiao, Shichong
Qin, Hui
Jandt, Klaus D.
author_facet Cao, Huiliang
Qiao, Shichong
Qin, Hui
Jandt, Klaus D.
author_sort Cao, Huiliang
collection PubMed
description The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.
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spelling pubmed-93267562022-07-28 Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges Cao, Huiliang Qiao, Shichong Qin, Hui Jandt, Klaus D. J Funct Biomater Review The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations. MDPI 2022-06-21 /pmc/articles/PMC9326756/ /pubmed/35893454 http://dx.doi.org/10.3390/jfb13030086 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cao, Huiliang
Qiao, Shichong
Qin, Hui
Jandt, Klaus D.
Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges
title Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges
title_full Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges
title_fullStr Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges
title_full_unstemmed Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges
title_short Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges
title_sort antibacterial designs for implantable medical devices: evolutions and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326756/
https://www.ncbi.nlm.nih.gov/pubmed/35893454
http://dx.doi.org/10.3390/jfb13030086
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