Activation of P-glycoprotein and CYP 3A by Coptidis Rhizoma in vivo: Using cyclosporine as a probe substrate in rats

Coptidis Rhizoma (CR), the rhizome of Coptis chinensis FRANCH, is a popular Chinese herb. CR contains plenty of isoquinoline alkaloids such as berberine, coptisine and palmatine. Cyclosporine (CSP), an important immunosuppressant with narrow therapeutic window, is employed as a probe substrate of P-...

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Detalles Bibliográficos
Autores principales: Yu, Chung-Ping, Huang, Ching-Ya, Lin, Shiuan-Pey, Hou, Yu-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326880/
https://www.ncbi.nlm.nih.gov/pubmed/29703381
http://dx.doi.org/10.1016/j.jfda.2017.11.005

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