Cargando…

Integrin-directed antibody-based immunotherapy: focus on VLA-4

One major finding of chronic inflammatory diseases of various origins is the establishment of inflammatory infiltrates, bearing different leukocyte subpopulations, including activated T lymphocytes. Integrins are among the large series of molecular interactions that have been implicated as players i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Savino, Wilson, Chaves, Beatriz, Bonomo, Adriana Cesar, Cotta-de-Almeida, Vinicius
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327104/ https://www.ncbi.nlm.nih.gov/pubmed/35919739 http://dx.doi.org/10.1093/immadv/ltab002

Ejemplares similares

Guidelines To Predict Binding Poses of Antibody–Integrin Complexes
por: Chaves, Beatriz, et al.
Publicado: (2020)

Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture
Publicado: (1992)

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
Publicado: (1991)

Antiphospholipid Antibody Syndrome-Associated Increased Surface Expression of VLA4 Integrin on Human Monocytes
por: Štok, Ula, et al.
Publicado: (2022)

Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins
Publicado: (1995)

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
Publicado: (1995)

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit
Publicado: (1992)

VLA2 integrin expression in breast carcinomas evaluated by automated and quantitative immunohistochemistry.
por: Charpin, C., et al.
Publicado: (1998)

G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells
por: Madrazo, Elena, et al.
Publicado: (2018)

Integrin VLA-3: ultrastructural localization at cell-cell contact sites of human cell cultures
Publicado: (1989)

Therapeutic effect of all-trans-retinoic acid (at-RA) on an autoimmune nephritis experimental model: role of the VLA-4 integrin
por: Escribese, María M, et al.
Publicado: (2007)

Enhanced Migratory Capacity of T Lymphocytes in Severe Chagasic Patients Is Correlated With VLA-4 and TNF-α Expression
por: Berbert, Luiz Ricardo, et al.
Publicado: (2021)

Cell adhesion and migration are regulated at distinct stages of thymic T cell development: the roles of fibronectin, VLA4, and VLA5
Publicado: (1996)

An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1- independent, triggered through the human VLA-4 integrin
Publicado: (1990)

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions
por: Azcutia, Veronica, et al.
Publicado: (2013)

Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development
Publicado: (1990)

Editorial: T-Cell Migration in Health and Disease
por: Cotta-de-Almeida, Vinicius, et al.
Publicado: (2017)

CNS accumulation of regulatory B cells is VLA-4-dependent
por: Lehmann-Horn, Klaus, et al.
Publicado: (2016)

Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family
Publicado: (1990)

A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA- dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components
Publicado: (1992)

Integrin VLA-5 and FAK are Good Targets to Improve Treatment Response in the Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
por: Hu, Zhongbo, et al.
Publicado: (2014)

Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin
Publicado: (1993)

Expression and pathogenesis of VCAM-1 and VLA-4 cytokines in multiple myeloma
por: Hao, Pan, et al.
Publicado: (2020)

Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin
Publicado: (1993)

Alpha2beta1 Integrin (VLA-2) Protects Activated Human Effector T Cells From Methotrexate-Induced Apoptosis
por: Abderrazak, Amna, et al.
Publicado: (2018)

ROSAT/ASCA/VLA studies of solar proxies
por: Güdel, M, et al.
Publicado: (1996)

VLA-4 Expression and Activation in B Cell Malignancies: Functional and Clinical Aspects
por: Härzschel, Andrea, et al.
Publicado: (2020)

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
por: Li, Jiaqian, et al.
Publicado: (2022)

Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations
Publicado: (1991)

Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti- beta 1 antibody
Publicado: (1993)

Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion
por: Chigaev, Alexandre, et al.
Publicado: (2012)

Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival
por: Hathi, Deep, et al.
Publicado: (2022)

Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis
por: Gilon, Chaim, et al.
Publicado: (2021)

Role of Extracellular Matrix-Mediated Interactions in Thymocyte Migration
por: Savino, Wilson, et al.
Publicado: (2000)

Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein
Publicado: (1992)

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
Publicado: (1989)

Development of New Potential Inhibitors of β1 Integrins through In Silico Methods—Screening and Computational Validation
por: Vasconcelos, Disraeli, et al.
Publicado: (2022)

Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen
Publicado: (1991)

The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain
Publicado: (1989)

The L1 adhesion molecule is a cellular ligand for VLA-5
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_bbg0qvsk4vlbq2svkrtc2qm00h