Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

BACKGROUND: The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis. METHODS: Here, we use a mouse model that is deficient in Abi3 locus to study how the loss of function of Abi3 impac...

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Detalles Bibliográficos
Autores principales: Ibanez, Kristen R., McFarland, Karen N., Phillips, Jennifer, Allen, Mariet, Lessard, Christian B., Zobel, Lillian, De La Cruz, Elsa Gonzalez, Shah, Shivani, Vo, Quan, Wang, Xue, Quicksall, Zachary, Ryu, Daniel, Funk, Cory, Ertekin-Taner, Nilüfer, Prokop, Stefan, Golde, Todd E., Chakrabarty, Paramita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327202/
https://www.ncbi.nlm.nih.gov/pubmed/35897046
http://dx.doi.org/10.1186/s13195-022-01044-1

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