DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

BACKGROUND: Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC). METHODS: We performed whole genome bisulfite sequencing and transcriptome sequencing in 62 primary and recurrent tumors from 28 patients with stage III/...

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Detalles Bibliográficos
Autores principales: Gull, Nicole, Jones, Michelle R., Peng, Pei-Chen, Coetzee, Simon G., Silva, Tiago C., Plummer, Jasmine T., Reyes, Alberto Luiz P., Davis, Brian D., Chen, Stephanie S., Lawrenson, Kate, Lester, Jenny, Walsh, Christine, Rimel, Bobbie J., Li, Andrew J., Cass, Ilana, Berg, Yonatan, Govindavari, John-Paul B., Rutgers, Joanna K. L., Berman, Benjamin P., Karlan, Beth Y., Gayther, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327231/
https://www.ncbi.nlm.nih.gov/pubmed/35883104
http://dx.doi.org/10.1186/s13046-022-02440-z

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