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The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis
OBJECTIVES: To investigate longitudinal relationship between serum uric acid (SUA) and disease activity among Chinese males with axial spondyloarthritis (axSpA). METHODS: Two-year data from the NASA study cohort of male patients with axial spondyloarthritis were analyzed. Patients global assessment...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327298/ https://www.ncbi.nlm.nih.gov/pubmed/35897055 http://dx.doi.org/10.1186/s12891-022-05657-3 |
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author | Cai, Meimei Liu, Wen Wu, Yuanhui Zheng, Qing Liu, Dehao Shi, Guixiu |
author_facet | Cai, Meimei Liu, Wen Wu, Yuanhui Zheng, Qing Liu, Dehao Shi, Guixiu |
author_sort | Cai, Meimei |
collection | PubMed |
description | OBJECTIVES: To investigate longitudinal relationship between serum uric acid (SUA) and disease activity among Chinese males with axial spondyloarthritis (axSpA). METHODS: Two-year data from the NASA study cohort of male patients with axial spondyloarthritis were analyzed. Patients global assessment of disease activity (PtGA), BASDAI, ASDAS-CRP, BASFI, and SF-36 were used as the outcomes. The autoregressive Generalized Estimation Equation (GEE) model was used to investigate the longitudinal relationship between SUA and the above outcomes. Age and gender and symptom duration were tested as effect modifiers or confounders. RESULTS: In total, 102 male axSpA patients were included, 33.3% of who were hyperuricemia at baseline. Over time,serum uric acid levels associated with the global assessment of patient global assessment of disease activity (PtGA)[P=0.041, β=-2.059,95%CI(-4.032, -0.086)], SF-36: Vitality (VT) [P=0.01, β=1.751, 95%CI (0.415,3.087)], SF-36: Social Functioning (SF)[P=0.002, β= 2.968,95%CI (1.067,4.869)]). And these relationgships were independent of age, symptom duration, baseline uric acid levels, and medication use. CONCLUSIONS: In summary, SUA levels is longitudinally related to PtGA and mental health assessment. Age, gender and symptom duration do not have an impact on the relationships. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05657-3. |
format | Online Article Text |
id | pubmed-9327298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93272982022-07-28 The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis Cai, Meimei Liu, Wen Wu, Yuanhui Zheng, Qing Liu, Dehao Shi, Guixiu BMC Musculoskelet Disord Research OBJECTIVES: To investigate longitudinal relationship between serum uric acid (SUA) and disease activity among Chinese males with axial spondyloarthritis (axSpA). METHODS: Two-year data from the NASA study cohort of male patients with axial spondyloarthritis were analyzed. Patients global assessment of disease activity (PtGA), BASDAI, ASDAS-CRP, BASFI, and SF-36 were used as the outcomes. The autoregressive Generalized Estimation Equation (GEE) model was used to investigate the longitudinal relationship between SUA and the above outcomes. Age and gender and symptom duration were tested as effect modifiers or confounders. RESULTS: In total, 102 male axSpA patients were included, 33.3% of who were hyperuricemia at baseline. Over time,serum uric acid levels associated with the global assessment of patient global assessment of disease activity (PtGA)[P=0.041, β=-2.059,95%CI(-4.032, -0.086)], SF-36: Vitality (VT) [P=0.01, β=1.751, 95%CI (0.415,3.087)], SF-36: Social Functioning (SF)[P=0.002, β= 2.968,95%CI (1.067,4.869)]). And these relationgships were independent of age, symptom duration, baseline uric acid levels, and medication use. CONCLUSIONS: In summary, SUA levels is longitudinally related to PtGA and mental health assessment. Age, gender and symptom duration do not have an impact on the relationships. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05657-3. BioMed Central 2022-07-27 /pmc/articles/PMC9327298/ /pubmed/35897055 http://dx.doi.org/10.1186/s12891-022-05657-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Cai, Meimei Liu, Wen Wu, Yuanhui Zheng, Qing Liu, Dehao Shi, Guixiu The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
title | The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
title_full | The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
title_fullStr | The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
title_full_unstemmed | The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
title_short | The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
title_sort | serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327298/ https://www.ncbi.nlm.nih.gov/pubmed/35897055 http://dx.doi.org/10.1186/s12891-022-05657-3 |
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