Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential

Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fib...

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Autores principales: Liu, Pinyan, Mao, Yongcui, Xie, Ye, Wei, Jiayun, Yao, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327386/
https://www.ncbi.nlm.nih.gov/pubmed/35883127
http://dx.doi.org/10.1186/s13287-022-03041-5
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author Liu, Pinyan
Mao, Yongcui
Xie, Ye
Wei, Jiayun
Yao, Jia
author_facet Liu, Pinyan
Mao, Yongcui
Xie, Ye
Wei, Jiayun
Yao, Jia
author_sort Liu, Pinyan
collection PubMed
description Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of various cell sources, cell doses, and delivery methods. We also describe the limitations and strengths of various stem cells in clinical applications. Furthermore, to clarify how stem cells play a therapeutic role in liver fibrosis, we discuss the molecular mechanisms of stem cells for treatment of liver fibrosis, including liver regeneration, immunoregulation, resistance to injury, myofibroblast repression, and extracellular matrix degradation. We provide a perspective for the prospects of future clinical implementation of stem cells.
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spelling pubmed-93273862022-07-28 Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential Liu, Pinyan Mao, Yongcui Xie, Ye Wei, Jiayun Yao, Jia Stem Cell Res Ther Review Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of various cell sources, cell doses, and delivery methods. We also describe the limitations and strengths of various stem cells in clinical applications. Furthermore, to clarify how stem cells play a therapeutic role in liver fibrosis, we discuss the molecular mechanisms of stem cells for treatment of liver fibrosis, including liver regeneration, immunoregulation, resistance to injury, myofibroblast repression, and extracellular matrix degradation. We provide a perspective for the prospects of future clinical implementation of stem cells. BioMed Central 2022-07-26 /pmc/articles/PMC9327386/ /pubmed/35883127 http://dx.doi.org/10.1186/s13287-022-03041-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Pinyan
Mao, Yongcui
Xie, Ye
Wei, Jiayun
Yao, Jia
Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
title Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
title_full Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
title_fullStr Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
title_full_unstemmed Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
title_short Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
title_sort stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327386/
https://www.ncbi.nlm.nih.gov/pubmed/35883127
http://dx.doi.org/10.1186/s13287-022-03041-5
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