Depletion of CLL cells by venetoclax treatment reverses oxidative stress and impaired glycolysis in CD4 T cells

Acquired T-cell dysfunction is characteristic of chronic lymphocytic leukemia (CLL) and is associated with reduced efficacy of T cell–based therapies. A recently described feature of dysfunctional CLL-derived CD8 T cells is reduced metabolic plasticity. To what extend CD4 T cells are affected and wh...

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Detalles Bibliográficos
Autores principales: van Bruggen, J. A. C., van der Windt, G. J. W., Hoogendoorn, M., Dubois, J., Kater, Arnon P., Peters, F. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Clinical Trials and Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327552/
https://www.ncbi.nlm.nih.gov/pubmed/35580333
http://dx.doi.org/10.1182/bloodadvances.2022007034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327552/
https://www.ncbi.nlm.nih.gov/pubmed/35580333
http://dx.doi.org/10.1182/bloodadvances.2022007034

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