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Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?

BACKGROUND: No international standards include vitamin D levels at diagnosis or during treatment. It is included in the Children's Oncology Group long‐term follow‐up guidelines. However, bone health complications (like osteopenia and atraumatic fractures) can occur at diagnosis or during treatm...

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Autores principales: Naeije, Leonie, de Silva, Mandy Pohlui, Hofman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327654/
https://www.ncbi.nlm.nih.gov/pubmed/34704392
http://dx.doi.org/10.1002/cnr2.1534
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author Naeije, Leonie
de Silva, Mandy Pohlui
Hofman, Paul
author_facet Naeije, Leonie
de Silva, Mandy Pohlui
Hofman, Paul
author_sort Naeije, Leonie
collection PubMed
description BACKGROUND: No international standards include vitamin D levels at diagnosis or during treatment. It is included in the Children's Oncology Group long‐term follow‐up guidelines. However, bone health complications (like osteopenia and atraumatic fractures) can occur at diagnosis or during treatment as well. CASES: In this small case series, we illustrate the complexity of bone health complications among our broad paediatric oncology population. If the vitamin D level is low we supplement the patient with one standard oral dose (150 000 units for 1–2 year olds, 300 000 units for 2–5 year olds and 600 000 units for >5 year olds). We do not adjust depending on diagnosis. CONCLUSION: Because of the potentially negative outcomes on short, medium and long term, we recommend checking vitamin D levels on diagnosis for all newly diagnosed patients. It is a simple, low cost test and one dose of oral supplementation can easily treat the deficiency.
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spelling pubmed-93276542022-07-30 Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients? Naeije, Leonie de Silva, Mandy Pohlui Hofman, Paul Cancer Rep (Hoboken) Case Series BACKGROUND: No international standards include vitamin D levels at diagnosis or during treatment. It is included in the Children's Oncology Group long‐term follow‐up guidelines. However, bone health complications (like osteopenia and atraumatic fractures) can occur at diagnosis or during treatment as well. CASES: In this small case series, we illustrate the complexity of bone health complications among our broad paediatric oncology population. If the vitamin D level is low we supplement the patient with one standard oral dose (150 000 units for 1–2 year olds, 300 000 units for 2–5 year olds and 600 000 units for >5 year olds). We do not adjust depending on diagnosis. CONCLUSION: Because of the potentially negative outcomes on short, medium and long term, we recommend checking vitamin D levels on diagnosis for all newly diagnosed patients. It is a simple, low cost test and one dose of oral supplementation can easily treat the deficiency. John Wiley and Sons Inc. 2021-10-26 /pmc/articles/PMC9327654/ /pubmed/34704392 http://dx.doi.org/10.1002/cnr2.1534 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Naeije, Leonie
de Silva, Mandy Pohlui
Hofman, Paul
Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?
title Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?
title_full Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?
title_fullStr Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?
title_full_unstemmed Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?
title_short Can screening for low vitamin D levels prevent bone health complications in paediatric oncology patients?
title_sort can screening for low vitamin d levels prevent bone health complications in paediatric oncology patients?
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327654/
https://www.ncbi.nlm.nih.gov/pubmed/34704392
http://dx.doi.org/10.1002/cnr2.1534
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