Cargando…

Successful pregnancy with stage IB2 uterine cervical cancer: A case report

BACKGROUND: Although cervical cancer is one of the most common malignancies in pregnancy, its management mainly follows the guidelines for nonpregnant disease state. Within the limited time, patients, and healthcare workers must make difficult decisions to either delay treatment until documented fet...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagasawa, Saya, Kasahara, Makiko, Aoki, Yuji, Kusunoki, Soshi, Sugimori, Yayoi, Matsuoka, Shozo, Ogura, Kanako, Ogishima, Daiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327669/
https://www.ncbi.nlm.nih.gov/pubmed/34528406
http://dx.doi.org/10.1002/cnr2.1542
_version_ 1784757560941740032
author Nagasawa, Saya
Kasahara, Makiko
Aoki, Yuji
Kusunoki, Soshi
Sugimori, Yayoi
Matsuoka, Shozo
Ogura, Kanako
Ogishima, Daiki
author_facet Nagasawa, Saya
Kasahara, Makiko
Aoki, Yuji
Kusunoki, Soshi
Sugimori, Yayoi
Matsuoka, Shozo
Ogura, Kanako
Ogishima, Daiki
author_sort Nagasawa, Saya
collection PubMed
description BACKGROUND: Although cervical cancer is one of the most common malignancies in pregnancy, its management mainly follows the guidelines for nonpregnant disease state. Within the limited time, patients, and healthcare workers must make difficult decisions to either delay treatment until documented fetal maturity or start immediate treatment based on the disease stage. CASE: The patient was a 37‐year‐old woman: gravida 1, para 0. Her cervical cytology revealed a high‐grade squamous intraepithelial lesion at 8 weeks' gestation. Moreover, invasive squamous cell carcinoma was suspected based on the findings of uterine cervix biopsy. Cervical conization was performed at 11 weeks' gestation, confirming a histopathological diagnosis of squamous cell carcinoma, pT1b2. Cervical cytology findings continued to be negative for intraepithelial lesion or malignancy from 2 weeks after conization until 2 weeks before a cesarean section. In addition, we performed abdominal pelvic lymphadenectomy at 16 weeks' gestation to determine whether the patient could continue her pregnancy. No lymph node metastasis or local recurrence was observed. Finally, a cesarean section and modified radical hysterectomy were performed at 35 weeks' gestation. There was no carcinoma invasion or metastasis. A baby girl weighing 2056 g was delivered with 1‐ and 5‐min Apgar scores of 8 and 9, respectively. Five years postoperatively, there was no evidence of cancer recurrence. CONCLUSION: Management of cervical cancer during pregnancy by using a combination strategy of deep conization and pelvic lymphadenectomy could be an effective strategy for carefully and safely assessing risks of recurrence and metastasis.
format Online
Article
Text
id pubmed-9327669
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93276692022-07-30 Successful pregnancy with stage IB2 uterine cervical cancer: A case report Nagasawa, Saya Kasahara, Makiko Aoki, Yuji Kusunoki, Soshi Sugimori, Yayoi Matsuoka, Shozo Ogura, Kanako Ogishima, Daiki Cancer Rep (Hoboken) Case Reports BACKGROUND: Although cervical cancer is one of the most common malignancies in pregnancy, its management mainly follows the guidelines for nonpregnant disease state. Within the limited time, patients, and healthcare workers must make difficult decisions to either delay treatment until documented fetal maturity or start immediate treatment based on the disease stage. CASE: The patient was a 37‐year‐old woman: gravida 1, para 0. Her cervical cytology revealed a high‐grade squamous intraepithelial lesion at 8 weeks' gestation. Moreover, invasive squamous cell carcinoma was suspected based on the findings of uterine cervix biopsy. Cervical conization was performed at 11 weeks' gestation, confirming a histopathological diagnosis of squamous cell carcinoma, pT1b2. Cervical cytology findings continued to be negative for intraepithelial lesion or malignancy from 2 weeks after conization until 2 weeks before a cesarean section. In addition, we performed abdominal pelvic lymphadenectomy at 16 weeks' gestation to determine whether the patient could continue her pregnancy. No lymph node metastasis or local recurrence was observed. Finally, a cesarean section and modified radical hysterectomy were performed at 35 weeks' gestation. There was no carcinoma invasion or metastasis. A baby girl weighing 2056 g was delivered with 1‐ and 5‐min Apgar scores of 8 and 9, respectively. Five years postoperatively, there was no evidence of cancer recurrence. CONCLUSION: Management of cervical cancer during pregnancy by using a combination strategy of deep conization and pelvic lymphadenectomy could be an effective strategy for carefully and safely assessing risks of recurrence and metastasis. John Wiley and Sons Inc. 2021-09-15 /pmc/articles/PMC9327669/ /pubmed/34528406 http://dx.doi.org/10.1002/cnr2.1542 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Nagasawa, Saya
Kasahara, Makiko
Aoki, Yuji
Kusunoki, Soshi
Sugimori, Yayoi
Matsuoka, Shozo
Ogura, Kanako
Ogishima, Daiki
Successful pregnancy with stage IB2 uterine cervical cancer: A case report
title Successful pregnancy with stage IB2 uterine cervical cancer: A case report
title_full Successful pregnancy with stage IB2 uterine cervical cancer: A case report
title_fullStr Successful pregnancy with stage IB2 uterine cervical cancer: A case report
title_full_unstemmed Successful pregnancy with stage IB2 uterine cervical cancer: A case report
title_short Successful pregnancy with stage IB2 uterine cervical cancer: A case report
title_sort successful pregnancy with stage ib2 uterine cervical cancer: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327669/
https://www.ncbi.nlm.nih.gov/pubmed/34528406
http://dx.doi.org/10.1002/cnr2.1542
work_keys_str_mv AT nagasawasaya successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT kasaharamakiko successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT aokiyuji successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT kusunokisoshi successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT sugimoriyayoi successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT matsuokashozo successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT ogurakanako successfulpregnancywithstageib2uterinecervicalcanceracasereport
AT ogishimadaiki successfulpregnancywithstageib2uterinecervicalcanceracasereport