Cargando…

Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review

OBJECTIVE: To review available data on tranexamic acid (TXA) plasma concentration needed to inhibit fibrinolysis and the time to achieve this concentration when giving TXA by different routes in humans. To identify ongoing trials assessing alternatives to intravenous TXA administration. METHODS: We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shakur‐Still, Haleema, Grassin‐Delyle, Stanislas, Muhunthan, Kopalasuntharam, Ahmadzia, Homa K., Faraoni, David, Arribas, Monica, Roberts, Ian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Supplement Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327714/ https://www.ncbi.nlm.nih.gov/pubmed/35762806 http://dx.doi.org/10.1002/ijgo.14201

Ejemplares similares

Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers
por: Kane, Zoe, et al.
Publicado: (2021)

Clinical Validation of a Volumetric Absorptive Micro-Sampling Device for Pharmacokinetic Studies With Tranexamic Acid
por: Grassin-Delyle, Stanislas, et al.
Publicado: (2021)

WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section
por: Arribas, Monica, et al.
Publicado: (2021)

Tranexamic acid by the intramuscular or intravenous route for the prevention of postpartum haemorrhage in women at increased risk: a randomised placebo-controlled trial (I’M WOMAN)
por: Brenner, Amy, et al.
Publicado: (2023)

Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration
por: Muhunthan, Kopalasuntharam, et al.
Publicado: (2020)

Acceptability of intramuscular injection of tranexamic acid in postpartum hemorrhage prevention
por: Cordes, Sophia A., et al.
Publicado: (2023)

Tranexamic acid for post-partum haemorrhage: What, who and when
por: Brenner, Amy, et al.
Publicado: (2019)

Effects of tranexamic acid treatment in severely and non‐severely injured trauma patients
por: Ageron, Francois‐Xavier, et al.
Publicado: (2022)

No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial
por: Dallaku, Kastriot, et al.
Publicado: (2019)

Tranexamic acid for gastrointestinal bleeding: can a reduction in the risk of death be discounted? A systematic review and meta-analysis of individual patient data from 64 724 bleeding patients
por: Ker, Katharine, et al.
Publicado: (2023)

Quality of oxytocin and tranexamic acid for the prevention and treatment of postpartum hemorrhage in Kenya, Nigeria, South Africa, and Tanzania
por: Ammerdorffer, Anne, et al.
Publicado: (2022)

Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial
por: Collier, Tim, et al.
Publicado: (2023)

Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials
por: Kolin, David A., et al.
Publicado: (2020)

A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan
por: Mahmood, Abda, et al.
Publicado: (2019)

What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies
por: Picetti, Roberto, et al.
Publicado: (2019)

The association between body mass index and postpartum hemorrhage after cesarean delivery
por: Whitley, Julia, et al.
Publicado: (2023)

Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis
por: Ker, Katharine, et al.
Publicado: (2023)

A cost-effectiveness and value of information analysis to inform future research of tranexamic acid for older adults experiencing mild traumatic brain injury
por: Williams, Jack, et al.
Publicado: (2022)

Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: study protocol for an international, randomised, double-blind, placebo-controlled trial
por: Ker, Katharine, et al.
Publicado: (2018)

The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial
por: Brenner, Amy, et al.
Publicado: (2018)

Secondary analysis of the WOMAN trial to explore the risk of sepsis after invasive treatments for postpartum hemorrhage
por: Cornelissen, Laura, et al.
Publicado: (2019)

Economic evaluation of tranexamic acid for the treatment of acute gastrointestinal bleeding: a cost-effectiveness analysis using data from the HALT-IT randomised controlled trial
por: Bazeer, Nuha, et al.
Publicado: (2022)

The Use of Tranexamic Acid to Prevent Postpartum Hemorrhage
por: Mielke, Ruth T., et al.
Publicado: (2020)

Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach
por: Williams, Jack, et al.
Publicado: (2020)

The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial
por: Shakur, Haleema, et al.
Publicado: (2010)

ptairMS: real-time processing and analysis of PTR-TOF-MS data for biomarker discovery in exhaled breath
por: Roquencourt, Camille, et al.
Publicado: (2022)

Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial
por: Huque, Sumaya, et al.
Publicado: (2018)

Tranexamic acid at cesarean delivery: drug‐error deaths
por: Moran, Neil F., et al.
Publicado: (2022)

Postpartum Hemorrhage and Tranexamic Acid: A Literature Review
por: Anaposala, Satvika, et al.
Publicado: (2023)

Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients
por: Ageron, Francois-Xavier, et al.
Publicado: (2020)

Comparison effect of intravenous tranexamic acid and misoprostol for postpartum haemorrhage
por: Sahhaf, Farnaz, et al.
Publicado: (2014)

FIGO recommendations on the management of postpartum hemorrhage 2022
por: Escobar, Maria Fernanda, et al.
Publicado: (2022)

Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis
por: Ker, Katharine, et al.
Publicado: (2012)

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial
por: Brenner, Amy, et al.
Publicado: (2020)

Trial management: we need a cadre of high-class triallists to deliver the answers that patients need
por: Beaumont, Danielle, et al.
Publicado: (2019)

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial
por: Shakur-Still, Haleema, et al.
Publicado: (2018)

Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms
por: Roberts, Ian, et al.
Publicado: (2017)

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): protocol and statistical analysis plan for a randomized controlled trial
por: Shakur, Haleema, et al.
Publicado: (2016)

Prostanoid Receptors Involved in Regulation of the Beating Rate of Neonatal Rat Cardiomyocytes
por: Mechiche, Hakima, et al.
Publicado: (2012)

Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation
por: Guerriero, Carla, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_s8j7r4hanb2ejg6k120c392796