Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation

In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and MCF-7 cell lines and were further investigated for...

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Detalles Bibliográficos
Autores principales: Taghour, Mohammed S., Mahdy, Hazem A., Gomaa, Maher H., Aglan, Ahmed, Eldeib, Mahmoud Gomaa, Elwan, Alaa, Dahab, Mohammed A., Elkaeed, Eslam B., Alsfouk, Aisha A., Khalifa, Mohamed M., Eissa, Ibrahim H., Elkady, Hazem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327782/
https://www.ncbi.nlm.nih.gov/pubmed/35875937
http://dx.doi.org/10.1080/14756366.2022.2103552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327782/
https://www.ncbi.nlm.nih.gov/pubmed/35875937
http://dx.doi.org/10.1080/14756366.2022.2103552

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