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Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328157/ https://www.ncbi.nlm.nih.gov/pubmed/35913894 http://dx.doi.org/10.20900/agmr20220004 |
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author | McMahan, Rachel H. Boe, Devin M. Walrath, Travis M. Idrovo, Juan-Pablo Kovacs, Elizabeth J. |
author_facet | McMahan, Rachel H. Boe, Devin M. Walrath, Travis M. Idrovo, Juan-Pablo Kovacs, Elizabeth J. |
author_sort | McMahan, Rachel H. |
collection | PubMed |
description | Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight the emerging data suggesting that age-mediated impairment of gut barrier integrity and dysbiosis of the fecal microbiome in older subjects may play a role in the heightened multi-organ responses seen in older patients. Studies aimed at exploring the contribution of intestinal dysfunction in age-related exacerbations of post-burn inflammatory responses could highlight novel therapeutic interventions that can be used to treat victims of burns and other traumatic injuries. |
format | Online Article Text |
id | pubmed-9328157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-93281572022-08-10 Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut McMahan, Rachel H. Boe, Devin M. Walrath, Travis M. Idrovo, Juan-Pablo Kovacs, Elizabeth J. Adv Geriatr Med Res Article Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight the emerging data suggesting that age-mediated impairment of gut barrier integrity and dysbiosis of the fecal microbiome in older subjects may play a role in the heightened multi-organ responses seen in older patients. Studies aimed at exploring the contribution of intestinal dysfunction in age-related exacerbations of post-burn inflammatory responses could highlight novel therapeutic interventions that can be used to treat victims of burns and other traumatic injuries. 2022 2022-06-28 /pmc/articles/PMC9328157/ /pubmed/35913894 http://dx.doi.org/10.20900/agmr20220004 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License. |
spellingShingle | Article McMahan, Rachel H. Boe, Devin M. Walrath, Travis M. Idrovo, Juan-Pablo Kovacs, Elizabeth J. Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut |
title | Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut |
title_full | Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut |
title_fullStr | Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut |
title_full_unstemmed | Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut |
title_short | Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut |
title_sort | aging, cutaneous burn injury and multi-organ complications: the role of the gut |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328157/ https://www.ncbi.nlm.nih.gov/pubmed/35913894 http://dx.doi.org/10.20900/agmr20220004 |
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