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Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut

Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight...

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Autores principales: McMahan, Rachel H., Boe, Devin M., Walrath, Travis M., Idrovo, Juan-Pablo, Kovacs, Elizabeth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328157/
https://www.ncbi.nlm.nih.gov/pubmed/35913894
http://dx.doi.org/10.20900/agmr20220004
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author McMahan, Rachel H.
Boe, Devin M.
Walrath, Travis M.
Idrovo, Juan-Pablo
Kovacs, Elizabeth J.
author_facet McMahan, Rachel H.
Boe, Devin M.
Walrath, Travis M.
Idrovo, Juan-Pablo
Kovacs, Elizabeth J.
author_sort McMahan, Rachel H.
collection PubMed
description Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight the emerging data suggesting that age-mediated impairment of gut barrier integrity and dysbiosis of the fecal microbiome in older subjects may play a role in the heightened multi-organ responses seen in older patients. Studies aimed at exploring the contribution of intestinal dysfunction in age-related exacerbations of post-burn inflammatory responses could highlight novel therapeutic interventions that can be used to treat victims of burns and other traumatic injuries.
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spelling pubmed-93281572022-08-10 Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut McMahan, Rachel H. Boe, Devin M. Walrath, Travis M. Idrovo, Juan-Pablo Kovacs, Elizabeth J. Adv Geriatr Med Res Article Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight the emerging data suggesting that age-mediated impairment of gut barrier integrity and dysbiosis of the fecal microbiome in older subjects may play a role in the heightened multi-organ responses seen in older patients. Studies aimed at exploring the contribution of intestinal dysfunction in age-related exacerbations of post-burn inflammatory responses could highlight novel therapeutic interventions that can be used to treat victims of burns and other traumatic injuries. 2022 2022-06-28 /pmc/articles/PMC9328157/ /pubmed/35913894 http://dx.doi.org/10.20900/agmr20220004 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License.
spellingShingle Article
McMahan, Rachel H.
Boe, Devin M.
Walrath, Travis M.
Idrovo, Juan-Pablo
Kovacs, Elizabeth J.
Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
title Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
title_full Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
title_fullStr Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
title_full_unstemmed Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
title_short Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut
title_sort aging, cutaneous burn injury and multi-organ complications: the role of the gut
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328157/
https://www.ncbi.nlm.nih.gov/pubmed/35913894
http://dx.doi.org/10.20900/agmr20220004
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