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Emergence of Candida auris in intensive care units in Algeria

BACKGROUND: Currently, Candida auris is among the most serious emerging pathogens that can be associated with nosocomial infections and outbreaks in intensive care units. Clinicians must be able to identify and manage it quickly. OBJECTIVE: Here, we report for the first time in Algeria seven cases o...

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Autores principales: Zerrouki, Hanane, Ibrahim, Ahmad, Rebiahi, Sid‐Ahmed, Elhabiri, Yamina, Benhaddouche, Djamel‐Eddine, de Groot, Theun, Meis, Jacques F., Rolain, Jean‐Marc, Bittar, Fadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328195/
https://www.ncbi.nlm.nih.gov/pubmed/35546294
http://dx.doi.org/10.1111/myc.13470
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author Zerrouki, Hanane
Ibrahim, Ahmad
Rebiahi, Sid‐Ahmed
Elhabiri, Yamina
Benhaddouche, Djamel‐Eddine
de Groot, Theun
Meis, Jacques F.
Rolain, Jean‐Marc
Bittar, Fadi
author_facet Zerrouki, Hanane
Ibrahim, Ahmad
Rebiahi, Sid‐Ahmed
Elhabiri, Yamina
Benhaddouche, Djamel‐Eddine
de Groot, Theun
Meis, Jacques F.
Rolain, Jean‐Marc
Bittar, Fadi
author_sort Zerrouki, Hanane
collection PubMed
description BACKGROUND: Currently, Candida auris is among the most serious emerging pathogens that can be associated with nosocomial infections and outbreaks in intensive care units. Clinicians must be able to identify and manage it quickly. OBJECTIVE: Here, we report for the first time in Algeria seven cases of C. auris infection or colonisation. METHODS AND RESULTS: The strains were isolated from clinical sites including bronchial aspirates (n = 4), wound swabs (n = 1), urine sample (n = 1) and peritoneal fluid (n = 1), in patients admitted to the intensive care unit. Candida auris was identified both by MALDI‐TOF and by sequencing the ITS region and the D1/D2 domain. Antifungal susceptibility testing was performed using the E‐test method. Non‐wildtype susceptibility was observed for five strains against fluconazole, itraconazole, voriconazole and caspofungin. Genotyping showed the presence of four clades (I–IV) in one hospital. CONCLUSIONS: Appropriate antifungal treatments with rapid and accurate microbial identification are the cornerstone for the management and control of C. auris infections.
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spelling pubmed-93281952022-07-30 Emergence of Candida auris in intensive care units in Algeria Zerrouki, Hanane Ibrahim, Ahmad Rebiahi, Sid‐Ahmed Elhabiri, Yamina Benhaddouche, Djamel‐Eddine de Groot, Theun Meis, Jacques F. Rolain, Jean‐Marc Bittar, Fadi Mycoses Original Articles BACKGROUND: Currently, Candida auris is among the most serious emerging pathogens that can be associated with nosocomial infections and outbreaks in intensive care units. Clinicians must be able to identify and manage it quickly. OBJECTIVE: Here, we report for the first time in Algeria seven cases of C. auris infection or colonisation. METHODS AND RESULTS: The strains were isolated from clinical sites including bronchial aspirates (n = 4), wound swabs (n = 1), urine sample (n = 1) and peritoneal fluid (n = 1), in patients admitted to the intensive care unit. Candida auris was identified both by MALDI‐TOF and by sequencing the ITS region and the D1/D2 domain. Antifungal susceptibility testing was performed using the E‐test method. Non‐wildtype susceptibility was observed for five strains against fluconazole, itraconazole, voriconazole and caspofungin. Genotyping showed the presence of four clades (I–IV) in one hospital. CONCLUSIONS: Appropriate antifungal treatments with rapid and accurate microbial identification are the cornerstone for the management and control of C. auris infections. John Wiley and Sons Inc. 2022-05-31 2022-07 /pmc/articles/PMC9328195/ /pubmed/35546294 http://dx.doi.org/10.1111/myc.13470 Text en © 2022 The Authors. Mycoses published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Zerrouki, Hanane
Ibrahim, Ahmad
Rebiahi, Sid‐Ahmed
Elhabiri, Yamina
Benhaddouche, Djamel‐Eddine
de Groot, Theun
Meis, Jacques F.
Rolain, Jean‐Marc
Bittar, Fadi
Emergence of Candida auris in intensive care units in Algeria
title Emergence of Candida auris in intensive care units in Algeria
title_full Emergence of Candida auris in intensive care units in Algeria
title_fullStr Emergence of Candida auris in intensive care units in Algeria
title_full_unstemmed Emergence of Candida auris in intensive care units in Algeria
title_short Emergence of Candida auris in intensive care units in Algeria
title_sort emergence of candida auris in intensive care units in algeria
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328195/
https://www.ncbi.nlm.nih.gov/pubmed/35546294
http://dx.doi.org/10.1111/myc.13470
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