Why we should sample sparsely and aim for a higher target: Lessons from model‐based therapeutic drug monitoring of vancomycin in intensive care patients

AIMS: To explore the optimal data sampling scheme and the pharmacokinetic (PK) target exposure on which dose computation is based in the model‐based therapeutic drug monitoring (TDM) practice of vancomycin in intensive care (ICU) patients. METHODS: We simulated concentration data for 1 day following...

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Detalles Bibliográficos
Autores principales: Guo, Tingjie, van Hest, Reinier M., Fleuren, Lucas M., Roggeveen, Luca F., Bosman, Rob J., van der Voort, Peter H.J., Girbes, Armand R.J., Mathot, Ron A.A., van Hasselt, Johan G.C., Elbers, Paul W.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328201/
https://www.ncbi.nlm.nih.gov/pubmed/32715505
http://dx.doi.org/10.1111/bcp.14498

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