Impact of enantiomer‐specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

AIMS: Ketorolac is a nonsteroidal anti‐inflammatory racemic drug with analgesic effects only attributed to its S‐enantiomer. The aim of this study is to quantify enantiomer‐specific maturational pharmacokinetics (PK) of ketorolac and investigate if the contribution of both enantiomers to the total k...

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Detalles Bibliográficos
Autores principales: Cloesmeijer, Michael E., van Esdonk, Michiel J., Lynn, Anne M., Smits, Anne, Tibboel, Dick, Daali, Youssef, Olkkola, Klaus T., Allegaert, Karel, Mian, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328374/
https://www.ncbi.nlm.nih.gov/pubmed/32901947
http://dx.doi.org/10.1111/bcp.14547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328374/
https://www.ncbi.nlm.nih.gov/pubmed/32901947
http://dx.doi.org/10.1111/bcp.14547

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