Impairment of endoxifen formation in tamoxifen‐treated premenopausal breast cancer patients carrying reduced‐function CYP2D6 alleles

AIMS: Tamoxifen is bioactivated to endoxifen by polymorphic CYP2D6‐dependent metabolism. Here, endoxifen levels were compared to CYP2D6 diplotypes, tentative target concentrations and side effects. METHODS: In total, 118 Swedish premenopausal breast cancer patients diagnosed 2006–2014, with on‐going...

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Detalles Bibliográficos
Autores principales: Thorén, Linda, Lindh, Jonatan D., Ackehed, Gerd, Kringen, Marianne Kristiansen, Hall, Per, Bergh, Jonas, Molden, Espen, Margolin, Sara, Eliasson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328423/
https://www.ncbi.nlm.nih.gov/pubmed/32713032
http://dx.doi.org/10.1111/bcp.14500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328423/
https://www.ncbi.nlm.nih.gov/pubmed/32713032
http://dx.doi.org/10.1111/bcp.14500

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