NH‐sulfoximine: A novel pharmacological inhibitor of the mitochondrial F(1)F(o)‐ATPase, which suppresses viability of cancerous cells

BACKGROUND AND PURPOSE: The mitochondrial F(1)F(o)‐ATPsynthase is pivotal for cellular homeostasis. When respiration is perturbed, its mode of action everts becoming an F(1)F(o)‐ATPase and therefore consuming rather producing ATP. Such a reversion is an obvious target for pharmacological interventio...

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Detalles Bibliográficos
Autores principales: Strobbe, Daniela, Pecorari, Rosalba, Conte, Oriana, Minutolo, Antonella, Hendriks, Christine M. M., Wiezorek, Stefan, Faccenda, Danilo, Abeti, Rosella, Montesano, Carla, Bolm, Carsten, Campanella, Michelangelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328437/
https://www.ncbi.nlm.nih.gov/pubmed/33037618
http://dx.doi.org/10.1111/bph.15279

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