Zafirlukast is a broad‐spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times

BACKGROUND AND PURPOSE: Multiple members of the thiol isomerase (TI) family of enzymes are present in and released by platelets. Inhibition of these enzymes results in diminished platelet responses, aggregation, adhesion and thrombus formation. Recently, the therapeutic potential of TI inhibition ha...

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Detalles Bibliográficos
Autores principales: Holbrook, Lisa‐Marie, Keeton, Shirley J., Sasikumar, Parvathy, Nock, Sophie, Gelzinis, Justine, Brunt, Elizabeth, Ryan, Sarah, Pantos, Megan M., Verbetsky, Christina A., Gibbins, Jonathan M., Kennedy, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328650/
https://www.ncbi.nlm.nih.gov/pubmed/33080041
http://dx.doi.org/10.1111/bph.15291

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