Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4

Mitochondrial quality in skeletal muscle is crucial for maintaining energy homeostasis during metabolic stresses. However, how muscle mitochondrial quality is controlled and its physiological impacts remain unclear. Here, we demonstrate that mitoprotease LONP1 is essential for preserving muscle mito...

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Detalles Bibliográficos
Autores principales: Guo, Qiqi, Xu, Zhisheng, Zhou, Danxia, Fu, Tingting, Wang, Wen, Sun, Wanping, Xiao, Liwei, Liu, Lin, Ding, Chenyun, Yin, Yujing, Zhou, Zheng, Sun, Zongchao, Zhu, Yuangang, Zhou, Wenjing, Jia, Yuhuan, Xue, Jiachen, Chen, Yuncong, Chen, Xiao-Wei, Piao, Hai-Long, Lu, Bin, Gan, Zhenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328690/
https://www.ncbi.nlm.nih.gov/pubmed/35895846
http://dx.doi.org/10.1126/sciadv.abo0340

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