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Fungal Mushrooms: A Natural Compound With Therapeutic Applications

Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal m...

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Autores principales: Chugh, Rishi Man, Mittal, Pooja, MP, Namratha, Arora, Tanu, Bhattacharya, Tanima, Chopra, Hitesh, Cavalu, Simona, Gautam, Rupesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328747/
https://www.ncbi.nlm.nih.gov/pubmed/35910346
http://dx.doi.org/10.3389/fphar.2022.925387
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author Chugh, Rishi Man
Mittal, Pooja
MP, Namratha
Arora, Tanu
Bhattacharya, Tanima
Chopra, Hitesh
Cavalu, Simona
Gautam, Rupesh K.
author_facet Chugh, Rishi Man
Mittal, Pooja
MP, Namratha
Arora, Tanu
Bhattacharya, Tanima
Chopra, Hitesh
Cavalu, Simona
Gautam, Rupesh K.
author_sort Chugh, Rishi Man
collection PubMed
description Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins.. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. Moreover, there are unanswered queries regarding its safety, efficacy, critical issues that affect the future mushroom medicine development, that could jeopardize its usage in the twenty-first century.
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spelling pubmed-93287472022-07-28 Fungal Mushrooms: A Natural Compound With Therapeutic Applications Chugh, Rishi Man Mittal, Pooja MP, Namratha Arora, Tanu Bhattacharya, Tanima Chopra, Hitesh Cavalu, Simona Gautam, Rupesh K. Front Pharmacol Pharmacology Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins.. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. Moreover, there are unanswered queries regarding its safety, efficacy, critical issues that affect the future mushroom medicine development, that could jeopardize its usage in the twenty-first century. Frontiers Media S.A. 2022-07-13 /pmc/articles/PMC9328747/ /pubmed/35910346 http://dx.doi.org/10.3389/fphar.2022.925387 Text en Copyright © 2022 Chugh, Mittal, MP, Arora, Bhattacharya, Chopra, Cavalu and Gautam. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chugh, Rishi Man
Mittal, Pooja
MP, Namratha
Arora, Tanu
Bhattacharya, Tanima
Chopra, Hitesh
Cavalu, Simona
Gautam, Rupesh K.
Fungal Mushrooms: A Natural Compound With Therapeutic Applications
title Fungal Mushrooms: A Natural Compound With Therapeutic Applications
title_full Fungal Mushrooms: A Natural Compound With Therapeutic Applications
title_fullStr Fungal Mushrooms: A Natural Compound With Therapeutic Applications
title_full_unstemmed Fungal Mushrooms: A Natural Compound With Therapeutic Applications
title_short Fungal Mushrooms: A Natural Compound With Therapeutic Applications
title_sort fungal mushrooms: a natural compound with therapeutic applications
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328747/
https://www.ncbi.nlm.nih.gov/pubmed/35910346
http://dx.doi.org/10.3389/fphar.2022.925387
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