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Induction of G(2)/M arrest and apoptosis through mitochondria pathway by a dimer sesquiterpene lactone from Smallanthus sonchifolius in HeLa cells
Dimer sesquiterpene lactones (SLs), uvedafolin and enhydrofolin, against four monomer SLs isolated from yacon, Smallanthus sonchifolius, leaf were the most cytotoxic substances on HeLa cells (IC(50) values 2.96–3.17 μM at 24 hours). However, the cytotoxic mechanism of dimer SL has not been elucidate...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taiwan Food and Drug Administration
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328826/ https://www.ncbi.nlm.nih.gov/pubmed/28911648 http://dx.doi.org/10.1016/j.jfda.2016.10.005 |