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Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021

Household transmission is a primary source of SARS-CoV-2 spread. We used COVID-19 epidemiologic investigation data and viral genome analysis data collected in the city of Kyoto, Japan, during January 2020–June 2021 to evaluate the effects of different settings and viral strains on SARS-CoV-2 transmi...

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Autores principales: Matsumura, Yasufumi, Nagao, Miki, Yamamoto, Masaki, Tsuchido, Yasuhiro, Noguchi, Taro, Shinohara, Koh, Yukawa, Satomi, Inoue, Hiromi, Ikeda, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328921/
https://www.ncbi.nlm.nih.gov/pubmed/35710464
http://dx.doi.org/10.3201/eid2808.220420
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author Matsumura, Yasufumi
Nagao, Miki
Yamamoto, Masaki
Tsuchido, Yasuhiro
Noguchi, Taro
Shinohara, Koh
Yukawa, Satomi
Inoue, Hiromi
Ikeda, Takeshi
author_facet Matsumura, Yasufumi
Nagao, Miki
Yamamoto, Masaki
Tsuchido, Yasuhiro
Noguchi, Taro
Shinohara, Koh
Yukawa, Satomi
Inoue, Hiromi
Ikeda, Takeshi
author_sort Matsumura, Yasufumi
collection PubMed
description Household transmission is a primary source of SARS-CoV-2 spread. We used COVID-19 epidemiologic investigation data and viral genome analysis data collected in the city of Kyoto, Japan, during January 2020–June 2021 to evaluate the effects of different settings and viral strains on SARS-CoV-2 transmission. Epidemiologic investigations of 5,061 COVID-19 cases found that the most common category for close contact was within households (35.3%); this category also had the highest reverse transcription PCR positivity. The prevalent viral lineage shifted from B.1.1.214 in the third wave to the Alpha variant in the fourth wave. The proportion of secondary cases associated with households also increased from the third to fourth waves (27% vs. 29%). Among 564 contacts from 206 households, Alpha variant was significantly associated with household transmission (odds ratio 1.52, 95% CI 1.06–2.18) compared with B.1.1.214. Public health interventions targeting household contacts and specific variants could help control SARS-CoV-2 transmission.
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spelling pubmed-93289212022-08-06 Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021 Matsumura, Yasufumi Nagao, Miki Yamamoto, Masaki Tsuchido, Yasuhiro Noguchi, Taro Shinohara, Koh Yukawa, Satomi Inoue, Hiromi Ikeda, Takeshi Emerg Infect Dis Research Household transmission is a primary source of SARS-CoV-2 spread. We used COVID-19 epidemiologic investigation data and viral genome analysis data collected in the city of Kyoto, Japan, during January 2020–June 2021 to evaluate the effects of different settings and viral strains on SARS-CoV-2 transmission. Epidemiologic investigations of 5,061 COVID-19 cases found that the most common category for close contact was within households (35.3%); this category also had the highest reverse transcription PCR positivity. The prevalent viral lineage shifted from B.1.1.214 in the third wave to the Alpha variant in the fourth wave. The proportion of secondary cases associated with households also increased from the third to fourth waves (27% vs. 29%). Among 564 contacts from 206 households, Alpha variant was significantly associated with household transmission (odds ratio 1.52, 95% CI 1.06–2.18) compared with B.1.1.214. Public health interventions targeting household contacts and specific variants could help control SARS-CoV-2 transmission. Centers for Disease Control and Prevention 2022-08 /pmc/articles/PMC9328921/ /pubmed/35710464 http://dx.doi.org/10.3201/eid2808.220420 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Matsumura, Yasufumi
Nagao, Miki
Yamamoto, Masaki
Tsuchido, Yasuhiro
Noguchi, Taro
Shinohara, Koh
Yukawa, Satomi
Inoue, Hiromi
Ikeda, Takeshi
Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
title Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
title_full Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
title_fullStr Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
title_full_unstemmed Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
title_short Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
title_sort transmissibility of sars-cov-2 b.1.1.214 and alpha variants during 4 covid-19 waves, kyoto, japan, january 2020–june 2021
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328921/
https://www.ncbi.nlm.nih.gov/pubmed/35710464
http://dx.doi.org/10.3201/eid2808.220420
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