Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple systems. Its clinical manifestation varies across patients, from skin mucosa to multiorgan damage to severe central nervous system involvement. The exosome has been shown to play an important role in the pathog...

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Detalles Bibliográficos
Autores principales: Fei, Yue, Liu, Qi, Peng, Na, Yang, Guocan, Shen, Ziwei, Hong, Pan, Wang, Shengjun, Rui, Ke, Cui, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328965/
https://www.ncbi.nlm.nih.gov/pubmed/35910853
http://dx.doi.org/10.1155/2022/8286498
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author Fei, Yue
Liu, Qi
Peng, Na
Yang, Guocan
Shen, Ziwei
Hong, Pan
Wang, Shengjun
Rui, Ke
Cui, Dawei
author_facet Fei, Yue
Liu, Qi
Peng, Na
Yang, Guocan
Shen, Ziwei
Hong, Pan
Wang, Shengjun
Rui, Ke
Cui, Dawei
author_sort Fei, Yue
collection PubMed
description Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple systems. Its clinical manifestation varies across patients, from skin mucosa to multiorgan damage to severe central nervous system involvement. The exosome has been shown to play an important role in the pathogenesis of autoimmune diseases, including SLE. We review the recent knowledge of exosomes, including their biology, functions, mechanism, and standardized extraction and purification methods in SLE, to highlight potential therapeutic targets for SLE.
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spelling pubmed-93289652022-07-28 Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus Fei, Yue Liu, Qi Peng, Na Yang, Guocan Shen, Ziwei Hong, Pan Wang, Shengjun Rui, Ke Cui, Dawei J Immunol Res Review Article Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple systems. Its clinical manifestation varies across patients, from skin mucosa to multiorgan damage to severe central nervous system involvement. The exosome has been shown to play an important role in the pathogenesis of autoimmune diseases, including SLE. We review the recent knowledge of exosomes, including their biology, functions, mechanism, and standardized extraction and purification methods in SLE, to highlight potential therapeutic targets for SLE. Hindawi 2022-07-20 /pmc/articles/PMC9328965/ /pubmed/35910853 http://dx.doi.org/10.1155/2022/8286498 Text en Copyright © 2022 Yue Fei et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fei, Yue
Liu, Qi
Peng, Na
Yang, Guocan
Shen, Ziwei
Hong, Pan
Wang, Shengjun
Rui, Ke
Cui, Dawei
Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
title Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
title_full Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
title_fullStr Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
title_full_unstemmed Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
title_short Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
title_sort exosomes as crucial players in pathogenesis of systemic lupus erythematosus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328965/
https://www.ncbi.nlm.nih.gov/pubmed/35910853
http://dx.doi.org/10.1155/2022/8286498
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