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ADAR1 averts fatal type I interferon induction by ZBP1

Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal necrosis(1–3). The IFN-inducible p150 isoform of ADAR1 contains a Zα domain that recognizes...

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Detalles Bibliográficos
Autores principales:	Jiao, Huipeng, Wachsmuth, Laurens, Wolf, Simone, Lohmann, Juliane, Nagata, Masahiro, Kaya, Göksu Gökberk, Oikonomou, Nikos, Kondylis, Vangelis, Rogg, Manuel, Diebold, Martin, Tröder, Simon E., Zevnik, Branko, Prinz, Marco, Schell, Christoph, Young, George R., Kassiotis, George, Pasparakis, Manolis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329096/ https://www.ncbi.nlm.nih.gov/pubmed/35859176 http://dx.doi.org/10.1038/s41586-022-04878-9

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