The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea

OBJECTIVE: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizo-phrenia. METHODS: We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to cal...

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Detalles Bibliográficos
Autores principales: Kim, Gyurin, Rim, Soo Jung, Jo, Minkyung, Lee, Min Geu, Park, Se Jin, Park, Subin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329102/
https://www.ncbi.nlm.nih.gov/pubmed/35879042
http://dx.doi.org/10.9758/cpn.2022.20.3.573
Descripción
Sumario:OBJECTIVE: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizo-phrenia. METHODS: We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high). RESULTS: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia. CONCLUSION: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.

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