The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea

OBJECTIVE: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizo-phrenia. METHODS: We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to cal...

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Autores principales: Kim, Gyurin, Rim, Soo Jung, Jo, Minkyung, Lee, Min Geu, Park, Se Jin, Park, Subin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329102/
https://www.ncbi.nlm.nih.gov/pubmed/35879042
http://dx.doi.org/10.9758/cpn.2022.20.3.573
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author Kim, Gyurin
Rim, Soo Jung
Jo, Minkyung
Lee, Min Geu
Park, Se Jin
Park, Subin
author_facet Kim, Gyurin
Rim, Soo Jung
Jo, Minkyung
Lee, Min Geu
Park, Se Jin
Park, Subin
author_sort Kim, Gyurin
collection PubMed
description OBJECTIVE: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizo-phrenia. METHODS: We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high). RESULTS: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia. CONCLUSION: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.
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spelling pubmed-93291022022-08-31 The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea Kim, Gyurin Rim, Soo Jung Jo, Minkyung Lee, Min Geu Park, Se Jin Park, Subin Clin Psychopharmacol Neurosci Brief Report OBJECTIVE: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizo-phrenia. METHODS: We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high). RESULTS: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia. CONCLUSION: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage. Korean College of Neuropsychopharmacology 2022-08-31 2022-08-31 /pmc/articles/PMC9329102/ /pubmed/35879042 http://dx.doi.org/10.9758/cpn.2022.20.3.573 Text en Copyright© 2022, Korean College of Neuropsychopharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Kim, Gyurin
Rim, Soo Jung
Jo, Minkyung
Lee, Min Geu
Park, Se Jin
Park, Subin
The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
title The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
title_full The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
title_fullStr The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
title_full_unstemmed The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
title_short The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
title_sort cumulative effect of antipsychotic usage on mortality in schizophrenia: a nationwide population-based cohort study in korea
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329102/
https://www.ncbi.nlm.nih.gov/pubmed/35879042
http://dx.doi.org/10.9758/cpn.2022.20.3.573
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