Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses

BACKGROUND: A rare coding variant, P522R, in the phospholipase C gamma 2 (PLCG2) gene has been identified as protective against late-onset Alzheimer’s disease (AD), but the mechanism is unknown. PLCG2 is exclusively expressed in microglia within the central nervous system, and altered microglial fun...

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Detalles Bibliográficos
Autores principales: Solomon, Shiden, Sampathkumar, Nirmal Kumar, Carre, Ivo, Mondal, Mrityunjoy, Chennell, George, Vernon, Anthony C., Ruepp, Marc-David, Mitchell, Jacqueline C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329165/
https://www.ncbi.nlm.nih.gov/pubmed/35895133
http://dx.doi.org/10.1007/s00018-022-04473-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329165/
https://www.ncbi.nlm.nih.gov/pubmed/35895133
http://dx.doi.org/10.1007/s00018-022-04473-1

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