Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors

OBJECTIVE: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual‐level genetic data available. METHODS: We calculated polygenic risk score to identify controls...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Dehestani, Mohammad, Blauwendraat, Cornelis, Makarious, Mary B., Leonard, Hampton, Kim, Jonggeol J., Schulte, Claudia, Noyce, Alastair, Jacobs, Benjamin M., Foote, Isabelle, Sharma, Manu, Nalls, Mike, Singleton, Andrew, Gasser, Thomas, Bandres‐Ciga, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329258/
https://www.ncbi.nlm.nih.gov/pubmed/35599344
http://dx.doi.org/10.1002/ana.26416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329258/
https://www.ncbi.nlm.nih.gov/pubmed/35599344
http://dx.doi.org/10.1002/ana.26416

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