Cargando…

Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors

OBJECTIVE: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual‐level genetic data available. METHODS: We calculated polygenic risk score to identify controls...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hui, Dehestani, Mohammad, Blauwendraat, Cornelis, Makarious, Mary B., Leonard, Hampton, Kim, Jonggeol J., Schulte, Claudia, Noyce, Alastair, Jacobs, Benjamin M., Foote, Isabelle, Sharma, Manu, Nalls, Mike, Singleton, Andrew, Gasser, Thomas, Bandres‐Ciga, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329258/ https://www.ncbi.nlm.nih.gov/pubmed/35599344 http://dx.doi.org/10.1002/ana.26416

Ejemplares similares

A population scale analysis of rare SNCA variation in the UK Biobank
por: Blauwendraat, Cornelis, et al.
Publicado: (2020)

Bidirectional relationship between olfaction and Parkinson’s disease
por: Kim, Jonggeol J., et al.
Publicado: (2023)

Analysis of rare Parkinson’s disease variants in millions of people
por: Pitz, Vanessa, et al.
Publicado: (2023)

The Parkinson's Disease DNA Variant Browser
por: Kim, Jonggeol J., et al.
Publicado: (2021)

Unhealthy Behaviours and Risk of Parkinson’s Disease: A Mendelian Randomisation Study
por: Heilbron, Karl, et al.
Publicado: (2021)

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis
por: Bandres‐Ciga, Sara, et al.
Publicado: (2019)

Genetic risk factor clustering within and across neurodegenerative diseases
por: Koretsky, Mathew J, et al.
Publicado: (2023)

Lower Lymphocyte Count is Associated With Increased Risk of Parkinson’s Disease
por: Jensen, Melanie P., et al.
Publicado: (2021)

Identification and prediction of Parkinson’s disease subtypes and progression using machine learning in two cohorts
por: Dadu, Anant, et al.
Publicado: (2022)

Parkinson’s disease determinants, prediction and gene–environment interactions in the UK Biobank
por: Jacobs, Benjamin Meir, et al.
Publicado: (2020)

Association of polygenic risk score with response to deep brain stimulation in Parkinson’s disease
por: Yoon, Esther, et al.
Publicado: (2023)

Effect Modification between Genes and Environment and Parkinson's Disease Risk
por: Periñán, Maria Teresa, et al.
Publicado: (2022)

RIC3 variants are not associated with Parkinson’s disease in large European, Latin American, or East Asian cohorts
por: Brolin, Kajsa, et al.
Publicado: (2022)

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative Diseases
por: Alvarado, Chelsea X., et al.
Publicado: (2023)

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
por: Bandres-Ciga, S., et al.
Publicado: (2020)

Correction to: Large‑scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
por: Bandres-Ciga, S., et al.
Publicado: (2021)

Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease
por: Blauwendraat, Cornelis, et al.
Publicado: (2021)

The Parkinson's Disease Mendelian Randomization Research Portal
por: Noyce, Alastair J., et al.
Publicado: (2019)

The Parkinson's Disease Genome‐Wide Association Study Locus Browser
por: Grenn, Francis P., et al.
Publicado: (2020)

Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson’s disease
por: Dehestani, Mohammad, et al.
Publicado: (2023)

Multi-modality machine learning predicting Parkinson’s disease
por: Makarious, Mary B., et al.
Publicado: (2022)

Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease
por: Dehestani, Mohammad, et al.
Publicado: (2021)

Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease
por: Alvarez Jerez, Pilar, et al.
Publicado: (2023)

Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s disease
por: Lake, Julie, et al.
Publicado: (2023)

Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead
por: Lake, Julie, et al.
Publicado: (2021)

Evaluating Lipid‐Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization
por: Williams, Dylan M., et al.
Publicado: (2020)

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk
por: Lake, Julie, et al.
Publicado: (2021)

MIDN locus structural variants and Parkinson's Disease risk
por: Billingsley, Kimberley J., et al.
Publicado: (2020)

Mendelian Randomization — the Key to Understanding Aspects of Parkinson's Disease Causation?
por: Noyce, Alastair J., et al.
Publicado: (2015)

Polygenic risk of Parkinson disease is correlated with disease age at onset
por: Escott‐Price, Valentina, et al.
Publicado: (2015)

Type 2 Diabetes as a Determinant of Parkinson’s Disease Risk and Progression
por: Chohan, Harneek, et al.
Publicado: (2021)

Insights on Genetic and Environmental Factors in Parkinson’s Disease from a Regional Swedish Case-Control Cohort
por: Brolin, Kajsa, et al.
Publicado: (2022)

Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study
por: Kang, Xiaoying, et al.
Publicado: (2021)

Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset
por: Billingsley, Kimberley J., et al.
Publicado: (2019)

No evidence for association between polygenic risk of multiple sclerosis and MRI phenotypes in ~30,000 healthy adult UK Biobank participants
por: Jacobs, Benjamin Meir, et al.
Publicado: (2022)

NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations
por: Bandres-Ciga, Sara, et al.
Publicado: (2023)

Black and African American Connections to Parkinson's Disease Study: Addressing Missing Diversity in Parkinson's Disease Genetics
por: Bandres‐Ciga, Sara
Publicado: (2022)

Human brain single nucleus cell type enrichments in neurodegenerative diseases
por: Alvarado, Chelsea X, et al.
Publicado: (2023)

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource
por: Iwaki, Hirotaka, et al.
Publicado: (2021)

Genome-wide case-only analysis of gene-gene interactions with known Parkinson’s disease risk variants reveals link between LRRK2 and SYT10
por: Aleknonytė-Resch, Milda, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_esrgpisbj2vjhr4klae66u93u8