Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy

ABSTRACT: Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS). This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate,...

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Detalles Bibliográficos
Autores principales: Maccari, Francesca, Rigon, Laura, Mantovani, Veronica, Galeotti, Fabio, Salvalaio, Marika, D’Avanzo, Francesca, Zanetti, Alessandra, Capitani, Federica, Gabrielli, Orazio, Tomanin, Rosella, Volpi, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329393/
https://www.ncbi.nlm.nih.gov/pubmed/35816218
http://dx.doi.org/10.1007/s00109-022-02221-3

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