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Avoiding collider bias in Mendelian randomization when performing stratified analyses

Mendelian randomization (MR) uses genetic variants as instrumental variables to investigate the causal effect of a risk factor on an outcome. A collider is a variable influenced by two or more other variables. Naive calculation of MR estimates in strata of the population defined by a collider, such...

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Detalles Bibliográficos
Autores principales:	Coscia, Claudia, Gill, Dipender, Benítez, Raquel, Pérez, Teresa, Malats, Núria, Burgess, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329404/ https://www.ncbi.nlm.nih.gov/pubmed/35639294 http://dx.doi.org/10.1007/s10654-022-00879-0

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