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Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns
In premature infants with an extremely low gestational age (ELGA, < 29 weeks GA), dysregulated changes in cerebral blood flow (CBF) are among the major pathogenic factors leading to germinal matrix/intraventricular hemorrhage (GM/IVH). Continuous monitoring of CBF can guide interventions to minim...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329437/ https://www.ncbi.nlm.nih.gov/pubmed/35896691 http://dx.doi.org/10.1038/s41598-022-16499-3 |
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author | Sunwoo, John Zavriyev, Alexander I. Kaya, Kutlu Martin, Alyssa Munster, Chelsea Steele, Tina Cuddyer, Deborah Sheldon, Yvonne Orihuela-Espina, Felipe Herzberg, Emily M. Inder, Terrie Franceschini, Maria Angela El-Dib, Mohamed |
author_facet | Sunwoo, John Zavriyev, Alexander I. Kaya, Kutlu Martin, Alyssa Munster, Chelsea Steele, Tina Cuddyer, Deborah Sheldon, Yvonne Orihuela-Espina, Felipe Herzberg, Emily M. Inder, Terrie Franceschini, Maria Angela El-Dib, Mohamed |
author_sort | Sunwoo, John |
collection | PubMed |
description | In premature infants with an extremely low gestational age (ELGA, < 29 weeks GA), dysregulated changes in cerebral blood flow (CBF) are among the major pathogenic factors leading to germinal matrix/intraventricular hemorrhage (GM/IVH). Continuous monitoring of CBF can guide interventions to minimize the risk of brain injury, but there are no clinically standard techniques or tools for its measurement. We report the feasibility of the continuous monitoring of CBF, including measures of autoregulation, via diffuse correlation spectroscopy (DCS) in ELGA infants using CBF variability and correlation with scalp blood flow (SBF, served as a surrogate measure of systemic perturbations). In nineteen ELGA infants (with 9 cases of GM/IVH) monitored for 6–24 h between days 2–5 of life, we found a strong correlation between CBF and SBF in severe IVH (Grade III or IV) and IVH diagnosed within 72 h of life, while CBF variability alone was not associated with IVH. The proposed method is potentially useful at the bedside for the prompt assessment of cerebral autoregulation and early identification of infants vulnerable to GM/IVH. |
format | Online Article Text |
id | pubmed-9329437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93294372022-07-29 Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns Sunwoo, John Zavriyev, Alexander I. Kaya, Kutlu Martin, Alyssa Munster, Chelsea Steele, Tina Cuddyer, Deborah Sheldon, Yvonne Orihuela-Espina, Felipe Herzberg, Emily M. Inder, Terrie Franceschini, Maria Angela El-Dib, Mohamed Sci Rep Article In premature infants with an extremely low gestational age (ELGA, < 29 weeks GA), dysregulated changes in cerebral blood flow (CBF) are among the major pathogenic factors leading to germinal matrix/intraventricular hemorrhage (GM/IVH). Continuous monitoring of CBF can guide interventions to minimize the risk of brain injury, but there are no clinically standard techniques or tools for its measurement. We report the feasibility of the continuous monitoring of CBF, including measures of autoregulation, via diffuse correlation spectroscopy (DCS) in ELGA infants using CBF variability and correlation with scalp blood flow (SBF, served as a surrogate measure of systemic perturbations). In nineteen ELGA infants (with 9 cases of GM/IVH) monitored for 6–24 h between days 2–5 of life, we found a strong correlation between CBF and SBF in severe IVH (Grade III or IV) and IVH diagnosed within 72 h of life, while CBF variability alone was not associated with IVH. The proposed method is potentially useful at the bedside for the prompt assessment of cerebral autoregulation and early identification of infants vulnerable to GM/IVH. Nature Publishing Group UK 2022-07-27 /pmc/articles/PMC9329437/ /pubmed/35896691 http://dx.doi.org/10.1038/s41598-022-16499-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sunwoo, John Zavriyev, Alexander I. Kaya, Kutlu Martin, Alyssa Munster, Chelsea Steele, Tina Cuddyer, Deborah Sheldon, Yvonne Orihuela-Espina, Felipe Herzberg, Emily M. Inder, Terrie Franceschini, Maria Angela El-Dib, Mohamed Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
title | Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
title_full | Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
title_fullStr | Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
title_full_unstemmed | Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
title_short | Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
title_sort | diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329437/ https://www.ncbi.nlm.nih.gov/pubmed/35896691 http://dx.doi.org/10.1038/s41598-022-16499-3 |
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