High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma

Upper tract urothelial carcinoma (UTUC) occurs in urothelial cells from the kidney and the ureters. Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker for pancreatic and gastrointestinal cancers, and its high levels are associated with poor prognosis in bladder cancer. In this study, prospective...

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Autores principales: Jeong, Seung-hwan, Han, Jang Hee, Jeong, Chang Wook, Kim, Hyeon Hoe, Kwak, Cheol, Yuk, Hyeong Dong, Ku, Ja Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329523/
https://www.ncbi.nlm.nih.gov/pubmed/35912192
http://dx.doi.org/10.3389/fonc.2022.858813
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author Jeong, Seung-hwan
Han, Jang Hee
Jeong, Chang Wook
Kim, Hyeon Hoe
Kwak, Cheol
Yuk, Hyeong Dong
Ku, Ja Hyeon
author_facet Jeong, Seung-hwan
Han, Jang Hee
Jeong, Chang Wook
Kim, Hyeon Hoe
Kwak, Cheol
Yuk, Hyeong Dong
Ku, Ja Hyeon
author_sort Jeong, Seung-hwan
collection PubMed
description Upper tract urothelial carcinoma (UTUC) occurs in urothelial cells from the kidney and the ureters. Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker for pancreatic and gastrointestinal cancers, and its high levels are associated with poor prognosis in bladder cancer. In this study, prospective patients enrolled in the registry of Seoul National University were retrospectively examined to determine the clinical significance of CA 19-9 in UTUC. In 227 patients, high serum CA 19-9 levels reflected a high tumor burden represented by high T and N stages, leading to adverse prognosis in metastasis-free or overall survival. Subsequently, propensity score matching analysis showed that the CA 19-9 level is an independent prognostic factor of UTUC.
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spelling pubmed-93295232022-07-29 High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma Jeong, Seung-hwan Han, Jang Hee Jeong, Chang Wook Kim, Hyeon Hoe Kwak, Cheol Yuk, Hyeong Dong Ku, Ja Hyeon Front Oncol Oncology Upper tract urothelial carcinoma (UTUC) occurs in urothelial cells from the kidney and the ureters. Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker for pancreatic and gastrointestinal cancers, and its high levels are associated with poor prognosis in bladder cancer. In this study, prospective patients enrolled in the registry of Seoul National University were retrospectively examined to determine the clinical significance of CA 19-9 in UTUC. In 227 patients, high serum CA 19-9 levels reflected a high tumor burden represented by high T and N stages, leading to adverse prognosis in metastasis-free or overall survival. Subsequently, propensity score matching analysis showed that the CA 19-9 level is an independent prognostic factor of UTUC. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9329523/ /pubmed/35912192 http://dx.doi.org/10.3389/fonc.2022.858813 Text en Copyright © 2022 Jeong, Han, Jeong, Kim, Kwak, Yuk and Ku https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jeong, Seung-hwan
Han, Jang Hee
Jeong, Chang Wook
Kim, Hyeon Hoe
Kwak, Cheol
Yuk, Hyeong Dong
Ku, Ja Hyeon
High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma
title High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma
title_full High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma
title_fullStr High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma
title_full_unstemmed High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma
title_short High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma
title_sort high carbohydrate antigen 19-9 levels indicate poor prognosis of upper tract urothelial carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329523/
https://www.ncbi.nlm.nih.gov/pubmed/35912192
http://dx.doi.org/10.3389/fonc.2022.858813
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