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Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients

INTRODUCTION: Accurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes and the patients’ cT stage. The study aimed to compare the performance of multiparametri...

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Autores principales: Marinescu, Ioana M., Spohn, Simon K. B., Kiefer, Selina, Bronsert, Peter, Ceci, Lara, Holzschuh, Julius, Sigle, August, Jilg, Cordula A., Rühle, Alexander, Sprave, Tanja, Nicolay, Nils H., Winzer, Robert, Rehm, Jana, Kotzerke, Jörg, Hölscher, Tobias, Grosu, Anca L., Ruf, Juri, Benndorf, Matthias, Zamboglou, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329567/
https://www.ncbi.nlm.nih.gov/pubmed/35912219
http://dx.doi.org/10.3389/fonc.2022.880042
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author Marinescu, Ioana M.
Spohn, Simon K. B.
Kiefer, Selina
Bronsert, Peter
Ceci, Lara
Holzschuh, Julius
Sigle, August
Jilg, Cordula A.
Rühle, Alexander
Sprave, Tanja
Nicolay, Nils H.
Winzer, Robert
Rehm, Jana
Kotzerke, Jörg
Hölscher, Tobias
Grosu, Anca L.
Ruf, Juri
Benndorf, Matthias
Zamboglou, Constantinos
author_facet Marinescu, Ioana M.
Spohn, Simon K. B.
Kiefer, Selina
Bronsert, Peter
Ceci, Lara
Holzschuh, Julius
Sigle, August
Jilg, Cordula A.
Rühle, Alexander
Sprave, Tanja
Nicolay, Nils H.
Winzer, Robert
Rehm, Jana
Kotzerke, Jörg
Hölscher, Tobias
Grosu, Anca L.
Ruf, Juri
Benndorf, Matthias
Zamboglou, Constantinos
author_sort Marinescu, Ioana M.
collection PubMed
description INTRODUCTION: Accurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes and the patients’ cT stage. The study aimed to compare the performance of multiparametric resonance imaging (mpMRI) with [(18)F] PSMA-1007 positron emission tomography (PET) for intraprostatic GTV detection as well as delineation and to evaluate their respective influence on RT concepts. MATERIALS AND METHODS: In total, 93 patients from two German University Hospitals with [(18)F] PSMA-1007-PET/CT and MRI (Freiburg) or [(18)F] PSMA-1007-PET/MRI (Dresden) were retrospectively enrolled. Validated contouring techniques were applied for GTV-PET and -MRI segmentation. Absolute tumor volume and cT status were determined for each imaging method. The PCa distribution from histopathological reports based on biopsy cores and surgery specimen was used as reference in terms of laterality (unilateral vs. bilateral). RESULTS: In the Freiburg cohort (n = 84), mpMRI and PET detected in median 2 (range: 1–5) and 3 (range: 1–8) GTVs, respectively (p < 0.01). The median GTV-MRI was significantly smaller than the GTV-PET, measuring 2.05 vs. 3.65 ml (p = 0.0005). PET had a statistically significant higher concordance in laterality with surgery specimen compared to mpMRI (p = 0.04) and biopsy (p < 0.01), respectively. PSMA PET led to more cT2c and cT3b stages, whereas cT3a stage was more pronounced in mpMRI. Based on the cT stage derived from mpMRI and PET information, 21 and 23 as well as 59 and 60 patients, respectively, were intermediate- and high-risk according to the National Comprehensive Cancer Network (NCCN) v1.2022 criteria. In the Dresden cohort (n = 9), similar results were observed. CONCLUSION: Intraprostatic GTV segmentation based on [18F] PSMA-1007 PET results in more and larger GTVs compared to mpMRI. This influences focal RT target volumes and cT stage definition, but not the NCCN risk group.
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spelling pubmed-93295672022-07-29 Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients Marinescu, Ioana M. Spohn, Simon K. B. Kiefer, Selina Bronsert, Peter Ceci, Lara Holzschuh, Julius Sigle, August Jilg, Cordula A. Rühle, Alexander Sprave, Tanja Nicolay, Nils H. Winzer, Robert Rehm, Jana Kotzerke, Jörg Hölscher, Tobias Grosu, Anca L. Ruf, Juri Benndorf, Matthias Zamboglou, Constantinos Front Oncol Oncology INTRODUCTION: Accurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes and the patients’ cT stage. The study aimed to compare the performance of multiparametric resonance imaging (mpMRI) with [(18)F] PSMA-1007 positron emission tomography (PET) for intraprostatic GTV detection as well as delineation and to evaluate their respective influence on RT concepts. MATERIALS AND METHODS: In total, 93 patients from two German University Hospitals with [(18)F] PSMA-1007-PET/CT and MRI (Freiburg) or [(18)F] PSMA-1007-PET/MRI (Dresden) were retrospectively enrolled. Validated contouring techniques were applied for GTV-PET and -MRI segmentation. Absolute tumor volume and cT status were determined for each imaging method. The PCa distribution from histopathological reports based on biopsy cores and surgery specimen was used as reference in terms of laterality (unilateral vs. bilateral). RESULTS: In the Freiburg cohort (n = 84), mpMRI and PET detected in median 2 (range: 1–5) and 3 (range: 1–8) GTVs, respectively (p < 0.01). The median GTV-MRI was significantly smaller than the GTV-PET, measuring 2.05 vs. 3.65 ml (p = 0.0005). PET had a statistically significant higher concordance in laterality with surgery specimen compared to mpMRI (p = 0.04) and biopsy (p < 0.01), respectively. PSMA PET led to more cT2c and cT3b stages, whereas cT3a stage was more pronounced in mpMRI. Based on the cT stage derived from mpMRI and PET information, 21 and 23 as well as 59 and 60 patients, respectively, were intermediate- and high-risk according to the National Comprehensive Cancer Network (NCCN) v1.2022 criteria. In the Dresden cohort (n = 9), similar results were observed. CONCLUSION: Intraprostatic GTV segmentation based on [18F] PSMA-1007 PET results in more and larger GTVs compared to mpMRI. This influences focal RT target volumes and cT stage definition, but not the NCCN risk group. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9329567/ /pubmed/35912219 http://dx.doi.org/10.3389/fonc.2022.880042 Text en Copyright © 2022 Marinescu, Spohn, Kiefer, Bronsert, Ceci, Holzschuh, Sigle, Jilg, Rühle, Sprave, Nicolay, Winzer, Rehm, Kotzerke, Hölscher, Grosu, Ruf, Benndorf and Zamboglou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Marinescu, Ioana M.
Spohn, Simon K. B.
Kiefer, Selina
Bronsert, Peter
Ceci, Lara
Holzschuh, Julius
Sigle, August
Jilg, Cordula A.
Rühle, Alexander
Sprave, Tanja
Nicolay, Nils H.
Winzer, Robert
Rehm, Jana
Kotzerke, Jörg
Hölscher, Tobias
Grosu, Anca L.
Ruf, Juri
Benndorf, Matthias
Zamboglou, Constantinos
Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
title Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
title_full Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
title_fullStr Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
title_full_unstemmed Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
title_short Intraindividual Comparison Between [(18)F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
title_sort intraindividual comparison between [(18)f] psma-1007 pet/ct and multiparametric mri for radiotherapy planning in primary prostate cancer patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329567/
https://www.ncbi.nlm.nih.gov/pubmed/35912219
http://dx.doi.org/10.3389/fonc.2022.880042
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