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Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review
BACKGROUND/AIMS: Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of gastric metastases of MM by systematically reviewing cases and case series involving patients diagnosed using...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Gastrointestinal Endoscopy
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329634/ https://www.ncbi.nlm.nih.gov/pubmed/35762131 http://dx.doi.org/10.5946/ce.2022.035 |
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author | Reggiani, Helena Campoli Pongeluppi, Ana Clara Aguiar Ferreira, Vitória Froes Miraglia Martins Felix, Isadora Pinheiro de Oliveira Campoli, Paulo Moacir |
author_facet | Reggiani, Helena Campoli Pongeluppi, Ana Clara Aguiar Ferreira, Vitória Froes Miraglia Martins Felix, Isadora Pinheiro de Oliveira Campoli, Paulo Moacir |
author_sort | Reggiani, Helena Campoli |
collection | PubMed |
description | BACKGROUND/AIMS: Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of gastric metastases of MM by systematically reviewing cases and case series involving patients diagnosed using upper gastrointestinal endoscopy. METHODS: The PubMed and LILACS databases were searched. Reports containing individual patient data were included. Outcomes such as clinical data, endoscopic findings, treatments, and survival were analyzed. RESULTS: A total of 88 studies with individual data from 113 patients with gastric metastases of MM were included. The primary sites of MM were the skin (62%), eyes (10%), and mucous membranes (6%). Most patients (56%) had multiple metastases in the stomach, located predominantly in the gastric body (approximately 80%). The overall survival rate at 2 years was 4%. There was a significant reduction in the survival of patients with multiple gastric metastases compared to that of patients with single metastasis (hazard ratio, 0.459; 95% confidence interval, 0.235−0.895; p=0.022). CONCLUSIONS: Gastric metastases of MM have a poor prognosis, especially in patients with multiple implants in the stomach. Additional studies are needed to verify whether ocular and mucosal melanomas are associated with a higher risk of gastric metastases than that of cutaneous melanomas. |
format | Online Article Text |
id | pubmed-9329634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society of Gastrointestinal Endoscopy |
record_format | MEDLINE/PubMed |
spelling | pubmed-93296342022-08-01 Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review Reggiani, Helena Campoli Pongeluppi, Ana Clara Aguiar Ferreira, Vitória Froes Miraglia Martins Felix, Isadora Pinheiro de Oliveira Campoli, Paulo Moacir Clin Endosc Systematic Review and Meta-Analysis BACKGROUND/AIMS: Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of gastric metastases of MM by systematically reviewing cases and case series involving patients diagnosed using upper gastrointestinal endoscopy. METHODS: The PubMed and LILACS databases were searched. Reports containing individual patient data were included. Outcomes such as clinical data, endoscopic findings, treatments, and survival were analyzed. RESULTS: A total of 88 studies with individual data from 113 patients with gastric metastases of MM were included. The primary sites of MM were the skin (62%), eyes (10%), and mucous membranes (6%). Most patients (56%) had multiple metastases in the stomach, located predominantly in the gastric body (approximately 80%). The overall survival rate at 2 years was 4%. There was a significant reduction in the survival of patients with multiple gastric metastases compared to that of patients with single metastasis (hazard ratio, 0.459; 95% confidence interval, 0.235−0.895; p=0.022). CONCLUSIONS: Gastric metastases of MM have a poor prognosis, especially in patients with multiple implants in the stomach. Additional studies are needed to verify whether ocular and mucosal melanomas are associated with a higher risk of gastric metastases than that of cutaneous melanomas. Korean Society of Gastrointestinal Endoscopy 2022-07 2022-06-28 /pmc/articles/PMC9329634/ /pubmed/35762131 http://dx.doi.org/10.5946/ce.2022.035 Text en Copyright © 2022 Korean Society of Gastrointestinal Endoscopy https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review and Meta-Analysis Reggiani, Helena Campoli Pongeluppi, Ana Clara Aguiar Ferreira, Vitória Froes Miraglia Martins Felix, Isadora Pinheiro de Oliveira Campoli, Paulo Moacir Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
title | Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
title_full | Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
title_fullStr | Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
title_full_unstemmed | Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
title_short | Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
title_sort | endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review |
topic | Systematic Review and Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329634/ https://www.ncbi.nlm.nih.gov/pubmed/35762131 http://dx.doi.org/10.5946/ce.2022.035 |
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