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Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients

Since the outbreak of the COVID-19 pandemic, races across academia and industry have been initiated to identify and develop disease modifying or preventative therapeutic strategies has been initiated. The primary focus has been on pharmacological treatment of the immune and respiratory system and th...

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Autores principales: Czura, Christopher J., Bikson, Marom, Charvet, Leigh, Chen, Jiande D. Z., Franke, Manfred, Fudim, Marat, Grigsby, Eric, Hamner, Sam, Huston, Jared M., Khodaparast, Navid, Krames, Elliot, Simon, Bruce J., Staats, Peter, Vonck, Kristl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329660/
https://www.ncbi.nlm.nih.gov/pubmed/35911909
http://dx.doi.org/10.3389/fneur.2022.897124
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author Czura, Christopher J.
Bikson, Marom
Charvet, Leigh
Chen, Jiande D. Z.
Franke, Manfred
Fudim, Marat
Grigsby, Eric
Hamner, Sam
Huston, Jared M.
Khodaparast, Navid
Krames, Elliot
Simon, Bruce J.
Staats, Peter
Vonck, Kristl
author_facet Czura, Christopher J.
Bikson, Marom
Charvet, Leigh
Chen, Jiande D. Z.
Franke, Manfred
Fudim, Marat
Grigsby, Eric
Hamner, Sam
Huston, Jared M.
Khodaparast, Navid
Krames, Elliot
Simon, Bruce J.
Staats, Peter
Vonck, Kristl
author_sort Czura, Christopher J.
collection PubMed
description Since the outbreak of the COVID-19 pandemic, races across academia and industry have been initiated to identify and develop disease modifying or preventative therapeutic strategies has been initiated. The primary focus has been on pharmacological treatment of the immune and respiratory system and the development of a vaccine. The hyperinflammatory state (“cytokine storm”) observed in many cases of COVID-19 indicates a prognostically negative disease progression that may lead to respiratory distress, multiple organ failure, shock, and death. Many critically ill patients continue to be at risk for significant, long-lasting morbidity or mortality. The human immune and respiratory systems are heavily regulated by the central nervous system, and intervention in the signaling of these neural pathways may permit targeted therapeutic control of excessive inflammation and pulmonary bronchoconstriction. Several technologies, both invasive and non-invasive, are available and approved for clinical use, but have not been extensively studied in treatment of the cytokine storm in COVID-19 patients. This manuscript provides an overview of the role of the nervous system in inflammation and respiration, the current understanding of neuromodulatory techniques from preclinical and clinical studies and provides a rationale for testing non-invasive neuromodulation to modulate acute systemic inflammation and respiratory dysfunction caused by SARS-CoV-2 and potentially other pathogens. The authors of this manuscript have co-founded the International Consortium on Neuromodulation for COVID-19 to advocate for and support studies of these technologies in the current coronavirus pandemic.
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spelling pubmed-93296602022-07-29 Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients Czura, Christopher J. Bikson, Marom Charvet, Leigh Chen, Jiande D. Z. Franke, Manfred Fudim, Marat Grigsby, Eric Hamner, Sam Huston, Jared M. Khodaparast, Navid Krames, Elliot Simon, Bruce J. Staats, Peter Vonck, Kristl Front Neurol Neurology Since the outbreak of the COVID-19 pandemic, races across academia and industry have been initiated to identify and develop disease modifying or preventative therapeutic strategies has been initiated. The primary focus has been on pharmacological treatment of the immune and respiratory system and the development of a vaccine. The hyperinflammatory state (“cytokine storm”) observed in many cases of COVID-19 indicates a prognostically negative disease progression that may lead to respiratory distress, multiple organ failure, shock, and death. Many critically ill patients continue to be at risk for significant, long-lasting morbidity or mortality. The human immune and respiratory systems are heavily regulated by the central nervous system, and intervention in the signaling of these neural pathways may permit targeted therapeutic control of excessive inflammation and pulmonary bronchoconstriction. Several technologies, both invasive and non-invasive, are available and approved for clinical use, but have not been extensively studied in treatment of the cytokine storm in COVID-19 patients. This manuscript provides an overview of the role of the nervous system in inflammation and respiration, the current understanding of neuromodulatory techniques from preclinical and clinical studies and provides a rationale for testing non-invasive neuromodulation to modulate acute systemic inflammation and respiratory dysfunction caused by SARS-CoV-2 and potentially other pathogens. The authors of this manuscript have co-founded the International Consortium on Neuromodulation for COVID-19 to advocate for and support studies of these technologies in the current coronavirus pandemic. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9329660/ /pubmed/35911909 http://dx.doi.org/10.3389/fneur.2022.897124 Text en Copyright © 2022 Czura, Bikson, Charvet, Chen, Franke, Fudim, Grigsby, Hamner, Huston, Khodaparast, Krames, Simon, Staats and Vonck. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Czura, Christopher J.
Bikson, Marom
Charvet, Leigh
Chen, Jiande D. Z.
Franke, Manfred
Fudim, Marat
Grigsby, Eric
Hamner, Sam
Huston, Jared M.
Khodaparast, Navid
Krames, Elliot
Simon, Bruce J.
Staats, Peter
Vonck, Kristl
Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients
title Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients
title_full Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients
title_fullStr Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients
title_full_unstemmed Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients
title_short Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients
title_sort neuromodulation strategies to reduce inflammation and improve lung complications in covid-19 patients
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329660/
https://www.ncbi.nlm.nih.gov/pubmed/35911909
http://dx.doi.org/10.3389/fneur.2022.897124
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