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Testicular Sertoli Cell Hormones in Differences in Sex Development

The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8(th) week of fetal...

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Autores principales: Lucas-Herald, Angela K., Mitchell, Rod T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329667/
https://www.ncbi.nlm.nih.gov/pubmed/35909548
http://dx.doi.org/10.3389/fendo.2022.919670
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author Lucas-Herald, Angela K.
Mitchell, Rod T.
author_facet Lucas-Herald, Angela K.
Mitchell, Rod T.
author_sort Lucas-Herald, Angela K.
collection PubMed
description The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8(th) week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.
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spelling pubmed-93296672022-07-29 Testicular Sertoli Cell Hormones in Differences in Sex Development Lucas-Herald, Angela K. Mitchell, Rod T. Front Endocrinol (Lausanne) Endocrinology The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8(th) week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9329667/ /pubmed/35909548 http://dx.doi.org/10.3389/fendo.2022.919670 Text en Copyright © 2022 Lucas-Herald and Mitchell https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lucas-Herald, Angela K.
Mitchell, Rod T.
Testicular Sertoli Cell Hormones in Differences in Sex Development
title Testicular Sertoli Cell Hormones in Differences in Sex Development
title_full Testicular Sertoli Cell Hormones in Differences in Sex Development
title_fullStr Testicular Sertoli Cell Hormones in Differences in Sex Development
title_full_unstemmed Testicular Sertoli Cell Hormones in Differences in Sex Development
title_short Testicular Sertoli Cell Hormones in Differences in Sex Development
title_sort testicular sertoli cell hormones in differences in sex development
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329667/
https://www.ncbi.nlm.nih.gov/pubmed/35909548
http://dx.doi.org/10.3389/fendo.2022.919670
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