Cargando…
Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-f...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329744/ https://www.ncbi.nlm.nih.gov/pubmed/35892462 http://dx.doi.org/10.3390/bios12080565 |
_version_ | 1784757989012406272 |
---|---|
author | Lv, Shan-Ling Zeng, Cong Yu, Zhou Zheng, Ju-Fang Wang, Ya-Hao Shao, Yong Zhou, Xiao-Shun |
author_facet | Lv, Shan-Ling Zeng, Cong Yu, Zhou Zheng, Ju-Fang Wang, Ya-Hao Shao, Yong Zhou, Xiao-Shun |
author_sort | Lv, Shan-Ling |
collection | PubMed |
description | Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity. |
format | Online Article Text |
id | pubmed-9329744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93297442022-07-29 Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements Lv, Shan-Ling Zeng, Cong Yu, Zhou Zheng, Ju-Fang Wang, Ya-Hao Shao, Yong Zhou, Xiao-Shun Biosensors (Basel) Review Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity. MDPI 2022-07-26 /pmc/articles/PMC9329744/ /pubmed/35892462 http://dx.doi.org/10.3390/bios12080565 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lv, Shan-Ling Zeng, Cong Yu, Zhou Zheng, Ju-Fang Wang, Ya-Hao Shao, Yong Zhou, Xiao-Shun Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements |
title | Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements |
title_full | Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements |
title_fullStr | Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements |
title_full_unstemmed | Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements |
title_short | Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements |
title_sort | recent advances in single-molecule sensors based on stm break junction measurements |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329744/ https://www.ncbi.nlm.nih.gov/pubmed/35892462 http://dx.doi.org/10.3390/bios12080565 |
work_keys_str_mv | AT lvshanling recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements AT zengcong recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements AT yuzhou recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements AT zhengjufang recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements AT wangyahao recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements AT shaoyong recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements AT zhouxiaoshun recentadvancesinsinglemoleculesensorsbasedonstmbreakjunctionmeasurements |