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Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements

Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-f...

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Autores principales: Lv, Shan-Ling, Zeng, Cong, Yu, Zhou, Zheng, Ju-Fang, Wang, Ya-Hao, Shao, Yong, Zhou, Xiao-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329744/
https://www.ncbi.nlm.nih.gov/pubmed/35892462
http://dx.doi.org/10.3390/bios12080565
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author Lv, Shan-Ling
Zeng, Cong
Yu, Zhou
Zheng, Ju-Fang
Wang, Ya-Hao
Shao, Yong
Zhou, Xiao-Shun
author_facet Lv, Shan-Ling
Zeng, Cong
Yu, Zhou
Zheng, Ju-Fang
Wang, Ya-Hao
Shao, Yong
Zhou, Xiao-Shun
author_sort Lv, Shan-Ling
collection PubMed
description Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity.
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spelling pubmed-93297442022-07-29 Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements Lv, Shan-Ling Zeng, Cong Yu, Zhou Zheng, Ju-Fang Wang, Ya-Hao Shao, Yong Zhou, Xiao-Shun Biosensors (Basel) Review Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity. MDPI 2022-07-26 /pmc/articles/PMC9329744/ /pubmed/35892462 http://dx.doi.org/10.3390/bios12080565 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lv, Shan-Ling
Zeng, Cong
Yu, Zhou
Zheng, Ju-Fang
Wang, Ya-Hao
Shao, Yong
Zhou, Xiao-Shun
Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
title Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
title_full Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
title_fullStr Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
title_full_unstemmed Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
title_short Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
title_sort recent advances in single-molecule sensors based on stm break junction measurements
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329744/
https://www.ncbi.nlm.nih.gov/pubmed/35892462
http://dx.doi.org/10.3390/bios12080565
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