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Degradation of Exogenous Fatty Acids in Escherichia coli

Many bacteria possess all the machineries required to grow on fatty acids (FA) as a unique source of carbon and energy. FA degradation proceeds through the β-oxidation cycle that produces acetyl-CoA and reduced NADH and FADH cofactors. In addition to all the enzymes required for β-oxidation, FA degr...

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Autores principales: Pavoncello, Viola, Barras, Frédéric, Bouveret, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329746/
https://www.ncbi.nlm.nih.gov/pubmed/35892328
http://dx.doi.org/10.3390/biom12081019
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author Pavoncello, Viola
Barras, Frédéric
Bouveret, Emmanuelle
author_facet Pavoncello, Viola
Barras, Frédéric
Bouveret, Emmanuelle
author_sort Pavoncello, Viola
collection PubMed
description Many bacteria possess all the machineries required to grow on fatty acids (FA) as a unique source of carbon and energy. FA degradation proceeds through the β-oxidation cycle that produces acetyl-CoA and reduced NADH and FADH cofactors. In addition to all the enzymes required for β-oxidation, FA degradation also depends on sophisticated systems for its genetic regulation and for FA transport. The fact that these machineries are conserved in bacteria suggests a crucial role in environmental conditions, especially for enterobacteria. Bacteria also possess specific enzymes required for the degradation of FAs from their environment, again showing the importance of this metabolism for bacterial adaptation. In this review, we mainly describe FA degradation in the Escherichia coli model, and along the way, we highlight and discuss important aspects of this metabolism that are still unclear. We do not detail exhaustively the diversity of the machineries found in other bacteria, but we mention them if they bring additional information or enlightenment on specific aspects.
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spelling pubmed-93297462022-07-29 Degradation of Exogenous Fatty Acids in Escherichia coli Pavoncello, Viola Barras, Frédéric Bouveret, Emmanuelle Biomolecules Review Many bacteria possess all the machineries required to grow on fatty acids (FA) as a unique source of carbon and energy. FA degradation proceeds through the β-oxidation cycle that produces acetyl-CoA and reduced NADH and FADH cofactors. In addition to all the enzymes required for β-oxidation, FA degradation also depends on sophisticated systems for its genetic regulation and for FA transport. The fact that these machineries are conserved in bacteria suggests a crucial role in environmental conditions, especially for enterobacteria. Bacteria also possess specific enzymes required for the degradation of FAs from their environment, again showing the importance of this metabolism for bacterial adaptation. In this review, we mainly describe FA degradation in the Escherichia coli model, and along the way, we highlight and discuss important aspects of this metabolism that are still unclear. We do not detail exhaustively the diversity of the machineries found in other bacteria, but we mention them if they bring additional information or enlightenment on specific aspects. MDPI 2022-07-22 /pmc/articles/PMC9329746/ /pubmed/35892328 http://dx.doi.org/10.3390/biom12081019 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pavoncello, Viola
Barras, Frédéric
Bouveret, Emmanuelle
Degradation of Exogenous Fatty Acids in Escherichia coli
title Degradation of Exogenous Fatty Acids in Escherichia coli
title_full Degradation of Exogenous Fatty Acids in Escherichia coli
title_fullStr Degradation of Exogenous Fatty Acids in Escherichia coli
title_full_unstemmed Degradation of Exogenous Fatty Acids in Escherichia coli
title_short Degradation of Exogenous Fatty Acids in Escherichia coli
title_sort degradation of exogenous fatty acids in escherichia coli
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329746/
https://www.ncbi.nlm.nih.gov/pubmed/35892328
http://dx.doi.org/10.3390/biom12081019
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