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Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation
In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, nam...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329780/ https://www.ncbi.nlm.nih.gov/pubmed/35897715 http://dx.doi.org/10.3390/ijms23158140 |
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author | Arleevskaya, Marina Takha, Elena Petrov, Sergey Kazarian, Gevorg Renaudineau, Yves Brooks, Wesley Larionova, Regina Korovina, Marina Valeeva, Anna Shuralev, Eduard Mukminov, Malik Kravtsova, Olga Novikov, Andrey |
author_facet | Arleevskaya, Marina Takha, Elena Petrov, Sergey Kazarian, Gevorg Renaudineau, Yves Brooks, Wesley Larionova, Regina Korovina, Marina Valeeva, Anna Shuralev, Eduard Mukminov, Malik Kravtsova, Olga Novikov, Andrey |
author_sort | Arleevskaya, Marina |
collection | PubMed |
description | In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-genetic factors form tangles of interdependent relationships and, thereby, several interdependent external factors hit one vulnerable basic process at once, either provoking or reinforcing each other. Understanding the specific mechanisms by which environmental and individual factors impact an individual under RA risk in the preclinical stages can contribute to early disease diagnosis and, if the factor is modifiable, might be useful for the prevention or delay of its development. |
format | Online Article Text |
id | pubmed-9329780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93297802022-07-29 Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation Arleevskaya, Marina Takha, Elena Petrov, Sergey Kazarian, Gevorg Renaudineau, Yves Brooks, Wesley Larionova, Regina Korovina, Marina Valeeva, Anna Shuralev, Eduard Mukminov, Malik Kravtsova, Olga Novikov, Andrey Int J Mol Sci Review In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-genetic factors form tangles of interdependent relationships and, thereby, several interdependent external factors hit one vulnerable basic process at once, either provoking or reinforcing each other. Understanding the specific mechanisms by which environmental and individual factors impact an individual under RA risk in the preclinical stages can contribute to early disease diagnosis and, if the factor is modifiable, might be useful for the prevention or delay of its development. MDPI 2022-07-23 /pmc/articles/PMC9329780/ /pubmed/35897715 http://dx.doi.org/10.3390/ijms23158140 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Arleevskaya, Marina Takha, Elena Petrov, Sergey Kazarian, Gevorg Renaudineau, Yves Brooks, Wesley Larionova, Regina Korovina, Marina Valeeva, Anna Shuralev, Eduard Mukminov, Malik Kravtsova, Olga Novikov, Andrey Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation |
title | Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation |
title_full | Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation |
title_fullStr | Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation |
title_full_unstemmed | Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation |
title_short | Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation |
title_sort | interplay of environmental, individual and genetic factors in rheumatoid arthritis provocation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329780/ https://www.ncbi.nlm.nih.gov/pubmed/35897715 http://dx.doi.org/10.3390/ijms23158140 |
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