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Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
OBJECTIVE: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. METHOD: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329808/ https://www.ncbi.nlm.nih.gov/pubmed/35909543 http://dx.doi.org/10.3389/fendo.2022.914812 |
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author | Shen, Xudong Chen, Yang Chen, Yan Liang, Hu Li, Guoxiang Hao, Zongyao |
author_facet | Shen, Xudong Chen, Yang Chen, Yan Liang, Hu Li, Guoxiang Hao, Zongyao |
author_sort | Shen, Xudong |
collection | PubMed |
description | OBJECTIVE: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. METHOD: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones. RESULT: This study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314. CONCLUSION: Higher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern. |
format | Online Article Text |
id | pubmed-9329808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93298082022-07-29 Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? Shen, Xudong Chen, Yang Chen, Yan Liang, Hu Li, Guoxiang Hao, Zongyao Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. METHOD: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones. RESULT: This study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314. CONCLUSION: Higher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9329808/ /pubmed/35909543 http://dx.doi.org/10.3389/fendo.2022.914812 Text en Copyright © 2022 Shen, Chen, Chen, Liang, Li and Hao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Shen, Xudong Chen, Yang Chen, Yan Liang, Hu Li, Guoxiang Hao, Zongyao Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? |
title | Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? |
title_full | Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? |
title_fullStr | Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? |
title_full_unstemmed | Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? |
title_short | Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? |
title_sort | is the mets-ir index a potential new biomarker for kidney stone development? |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329808/ https://www.ncbi.nlm.nih.gov/pubmed/35909543 http://dx.doi.org/10.3389/fendo.2022.914812 |
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