Cargando…

Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

OBJECTIVE: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. METHOD: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Xudong, Chen, Yang, Chen, Yan, Liang, Hu, Li, Guoxiang, Hao, Zongyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329808/
https://www.ncbi.nlm.nih.gov/pubmed/35909543
http://dx.doi.org/10.3389/fendo.2022.914812
_version_ 1784758005456175104
author Shen, Xudong
Chen, Yang
Chen, Yan
Liang, Hu
Li, Guoxiang
Hao, Zongyao
author_facet Shen, Xudong
Chen, Yang
Chen, Yan
Liang, Hu
Li, Guoxiang
Hao, Zongyao
author_sort Shen, Xudong
collection PubMed
description OBJECTIVE: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. METHOD: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones. RESULT: This study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314. CONCLUSION: Higher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern.
format Online
Article
Text
id pubmed-9329808
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93298082022-07-29 Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development? Shen, Xudong Chen, Yang Chen, Yan Liang, Hu Li, Guoxiang Hao, Zongyao Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. METHOD: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones. RESULT: This study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314. CONCLUSION: Higher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9329808/ /pubmed/35909543 http://dx.doi.org/10.3389/fendo.2022.914812 Text en Copyright © 2022 Shen, Chen, Chen, Liang, Li and Hao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Shen, Xudong
Chen, Yang
Chen, Yan
Liang, Hu
Li, Guoxiang
Hao, Zongyao
Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
title Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
title_full Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
title_fullStr Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
title_full_unstemmed Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
title_short Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?
title_sort is the mets-ir index a potential new biomarker for kidney stone development?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329808/
https://www.ncbi.nlm.nih.gov/pubmed/35909543
http://dx.doi.org/10.3389/fendo.2022.914812
work_keys_str_mv AT shenxudong isthemetsirindexapotentialnewbiomarkerforkidneystonedevelopment
AT chenyang isthemetsirindexapotentialnewbiomarkerforkidneystonedevelopment
AT chenyan isthemetsirindexapotentialnewbiomarkerforkidneystonedevelopment
AT lianghu isthemetsirindexapotentialnewbiomarkerforkidneystonedevelopment
AT liguoxiang isthemetsirindexapotentialnewbiomarkerforkidneystonedevelopment
AT haozongyao isthemetsirindexapotentialnewbiomarkerforkidneystonedevelopment