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COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B

Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe...

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Detalles Bibliográficos
Autores principales: García-Carmona, Salvador, Falfán-Valencia, Ramcés, Verónica-Aguilar, Abigail, Buendía-Roldán, Ivette, Chávez-Galán, Leslie, Hernández-Zenteno, Rafael de Jesús, Martínez-Morales, Alfonso, Fricke-Galindo, Ingrid, Alanis-Ponce, Jesús, Valencia-Pérez Rea, Daniela, Gutiérrez-Pérez, Ilse Adriana, Zaragoza-García, Oscar, Nava-Quiroz, Karol J., Camarena, Angel, Mejía, Mayra, Guzmán-Guzmán, Iris Paola, Pérez-Rubio, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329856/
https://www.ncbi.nlm.nih.gov/pubmed/35892712
http://dx.doi.org/10.3390/cimb44080226
Descripción
Sumario:Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe COVID-19, and whether plasma mucin 5B differs according to patients’ outcomes. Materials and methods: We included 1258 Mexican subjects diagnosed with COVID-19. We genotyped rs2892474 and rs17580 of the SERPINA1 gene and rs35705950 of MUC5B. Based on the rs35705950 genotypes, mucin 5B plasma protein levels were quantified. Results: Homozygous for the risk alleles of the three polymorphisms were found in less than 5% of the study population, but no statistically significant difference in the genotype or allele association analysis. At the protein level, non-survivors carrying one or two copies of the risk allele rs35705950 in MUC5B (GT + TT) had lower levels of mucin 5B compared to the survivors (0.0 vs. 0.17 ng/mL, p = 0.0013). Conclusion: The polymorphisms rs28929474 and rs17580 of SERPINA1 and rs35705950 of MUC5B are not associated with the risk of severe COVID-19 in the Mexican population. COVID-19 survivor patients bearing one or two copies of the rs35705950 risk allele have higher plasma levels of mucin 5B.