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COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B
Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329856/ https://www.ncbi.nlm.nih.gov/pubmed/35892712 http://dx.doi.org/10.3390/cimb44080226 |
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author | García-Carmona, Salvador Falfán-Valencia, Ramcés Verónica-Aguilar, Abigail Buendía-Roldán, Ivette Chávez-Galán, Leslie Hernández-Zenteno, Rafael de Jesús Martínez-Morales, Alfonso Fricke-Galindo, Ingrid Alanis-Ponce, Jesús Valencia-Pérez Rea, Daniela Gutiérrez-Pérez, Ilse Adriana Zaragoza-García, Oscar Nava-Quiroz, Karol J. Camarena, Angel Mejía, Mayra Guzmán-Guzmán, Iris Paola Pérez-Rubio, Gloria |
author_facet | García-Carmona, Salvador Falfán-Valencia, Ramcés Verónica-Aguilar, Abigail Buendía-Roldán, Ivette Chávez-Galán, Leslie Hernández-Zenteno, Rafael de Jesús Martínez-Morales, Alfonso Fricke-Galindo, Ingrid Alanis-Ponce, Jesús Valencia-Pérez Rea, Daniela Gutiérrez-Pérez, Ilse Adriana Zaragoza-García, Oscar Nava-Quiroz, Karol J. Camarena, Angel Mejía, Mayra Guzmán-Guzmán, Iris Paola Pérez-Rubio, Gloria |
author_sort | García-Carmona, Salvador |
collection | PubMed |
description | Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe COVID-19, and whether plasma mucin 5B differs according to patients’ outcomes. Materials and methods: We included 1258 Mexican subjects diagnosed with COVID-19. We genotyped rs2892474 and rs17580 of the SERPINA1 gene and rs35705950 of MUC5B. Based on the rs35705950 genotypes, mucin 5B plasma protein levels were quantified. Results: Homozygous for the risk alleles of the three polymorphisms were found in less than 5% of the study population, but no statistically significant difference in the genotype or allele association analysis. At the protein level, non-survivors carrying one or two copies of the risk allele rs35705950 in MUC5B (GT + TT) had lower levels of mucin 5B compared to the survivors (0.0 vs. 0.17 ng/mL, p = 0.0013). Conclusion: The polymorphisms rs28929474 and rs17580 of SERPINA1 and rs35705950 of MUC5B are not associated with the risk of severe COVID-19 in the Mexican population. COVID-19 survivor patients bearing one or two copies of the rs35705950 risk allele have higher plasma levels of mucin 5B. |
format | Online Article Text |
id | pubmed-9329856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93298562022-07-29 COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B García-Carmona, Salvador Falfán-Valencia, Ramcés Verónica-Aguilar, Abigail Buendía-Roldán, Ivette Chávez-Galán, Leslie Hernández-Zenteno, Rafael de Jesús Martínez-Morales, Alfonso Fricke-Galindo, Ingrid Alanis-Ponce, Jesús Valencia-Pérez Rea, Daniela Gutiérrez-Pérez, Ilse Adriana Zaragoza-García, Oscar Nava-Quiroz, Karol J. Camarena, Angel Mejía, Mayra Guzmán-Guzmán, Iris Paola Pérez-Rubio, Gloria Curr Issues Mol Biol Article Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe COVID-19, and whether plasma mucin 5B differs according to patients’ outcomes. Materials and methods: We included 1258 Mexican subjects diagnosed with COVID-19. We genotyped rs2892474 and rs17580 of the SERPINA1 gene and rs35705950 of MUC5B. Based on the rs35705950 genotypes, mucin 5B plasma protein levels were quantified. Results: Homozygous for the risk alleles of the three polymorphisms were found in less than 5% of the study population, but no statistically significant difference in the genotype or allele association analysis. At the protein level, non-survivors carrying one or two copies of the risk allele rs35705950 in MUC5B (GT + TT) had lower levels of mucin 5B compared to the survivors (0.0 vs. 0.17 ng/mL, p = 0.0013). Conclusion: The polymorphisms rs28929474 and rs17580 of SERPINA1 and rs35705950 of MUC5B are not associated with the risk of severe COVID-19 in the Mexican population. COVID-19 survivor patients bearing one or two copies of the rs35705950 risk allele have higher plasma levels of mucin 5B. MDPI 2022-07-22 /pmc/articles/PMC9329856/ /pubmed/35892712 http://dx.doi.org/10.3390/cimb44080226 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Carmona, Salvador Falfán-Valencia, Ramcés Verónica-Aguilar, Abigail Buendía-Roldán, Ivette Chávez-Galán, Leslie Hernández-Zenteno, Rafael de Jesús Martínez-Morales, Alfonso Fricke-Galindo, Ingrid Alanis-Ponce, Jesús Valencia-Pérez Rea, Daniela Gutiérrez-Pérez, Ilse Adriana Zaragoza-García, Oscar Nava-Quiroz, Karol J. Camarena, Angel Mejía, Mayra Guzmán-Guzmán, Iris Paola Pérez-Rubio, Gloria COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B |
title | COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B |
title_full | COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B |
title_fullStr | COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B |
title_full_unstemmed | COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B |
title_short | COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B |
title_sort | covid-19 survivor patients carrying the rs35705950 risk allele in muc5b have higher plasma levels of mucin 5b |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329856/ https://www.ncbi.nlm.nih.gov/pubmed/35892712 http://dx.doi.org/10.3390/cimb44080226 |
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