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Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic

Antibiotic-laden bone substitutes represent a viable option in the treatment of bone and joint infections with bone defects. In particular, the addition of silver ions or silver nanoparticles to bone substitutes to achieve local antiseptic activity could represent a further contribution, also helpin...

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Autores principales: Fiore, Michele, Bruschi, Alessandro, Giannini, Claudio, Morante, Lorenzo, Rondinella, Claudia, Filippini, Matteo, Sambri, Andrea, De Paolis, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329868/
https://www.ncbi.nlm.nih.gov/pubmed/35892385
http://dx.doi.org/10.3390/antibiotics11080995
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author Fiore, Michele
Bruschi, Alessandro
Giannini, Claudio
Morante, Lorenzo
Rondinella, Claudia
Filippini, Matteo
Sambri, Andrea
De Paolis, Massimiliano
author_facet Fiore, Michele
Bruschi, Alessandro
Giannini, Claudio
Morante, Lorenzo
Rondinella, Claudia
Filippini, Matteo
Sambri, Andrea
De Paolis, Massimiliano
author_sort Fiore, Michele
collection PubMed
description Antibiotic-laden bone substitutes represent a viable option in the treatment of bone and joint infections with bone defects. In particular, the addition of silver ions or silver nanoparticles to bone substitutes to achieve local antiseptic activity could represent a further contribution, also helping to prevent bacterial resistance to antibiotics. An in-depth search of the main scientific databases was performed regarding the use of silver compounds for bone substitution. The available evidence is still limited to the preclinical level: 22 laboratory studies, 2 animal models, and 3 studies, with both in vitro and in vivo analysis, were found on the topic. Numerous biomaterials have been evaluated. In vitro studies confirmed that silver in bone substitutes retains the antibacterial activity already demonstrated in coatings materials. Cytotoxicity was generally found to be low and only related to silver concentrations higher than those sufficient to achieve antibacterial activity. Instead, there are only a few in vivo studies, which appear to confirm antibacterial efficacy, although there is insufficient evidence on the pharmacokinetics and safety profile of the compounds investigated. In conclusion, research on bone substitutes doped with silver is in its early stages, but the preliminary findings seem promising.
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spelling pubmed-93298682022-07-29 Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic Fiore, Michele Bruschi, Alessandro Giannini, Claudio Morante, Lorenzo Rondinella, Claudia Filippini, Matteo Sambri, Andrea De Paolis, Massimiliano Antibiotics (Basel) Review Antibiotic-laden bone substitutes represent a viable option in the treatment of bone and joint infections with bone defects. In particular, the addition of silver ions or silver nanoparticles to bone substitutes to achieve local antiseptic activity could represent a further contribution, also helping to prevent bacterial resistance to antibiotics. An in-depth search of the main scientific databases was performed regarding the use of silver compounds for bone substitution. The available evidence is still limited to the preclinical level: 22 laboratory studies, 2 animal models, and 3 studies, with both in vitro and in vivo analysis, were found on the topic. Numerous biomaterials have been evaluated. In vitro studies confirmed that silver in bone substitutes retains the antibacterial activity already demonstrated in coatings materials. Cytotoxicity was generally found to be low and only related to silver concentrations higher than those sufficient to achieve antibacterial activity. Instead, there are only a few in vivo studies, which appear to confirm antibacterial efficacy, although there is insufficient evidence on the pharmacokinetics and safety profile of the compounds investigated. In conclusion, research on bone substitutes doped with silver is in its early stages, but the preliminary findings seem promising. MDPI 2022-07-24 /pmc/articles/PMC9329868/ /pubmed/35892385 http://dx.doi.org/10.3390/antibiotics11080995 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fiore, Michele
Bruschi, Alessandro
Giannini, Claudio
Morante, Lorenzo
Rondinella, Claudia
Filippini, Matteo
Sambri, Andrea
De Paolis, Massimiliano
Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic
title Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic
title_full Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic
title_fullStr Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic
title_full_unstemmed Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic
title_short Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic
title_sort is silver the new gold? a systematic review of the preclinical evidence of its use in bone substitutes as antiseptic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329868/
https://www.ncbi.nlm.nih.gov/pubmed/35892385
http://dx.doi.org/10.3390/antibiotics11080995
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