Genome-Wide Association Analysis and Genetic Parameters for Feed Efficiency and Related Traits in Yorkshire and Duroc Pigs

SIMPLE SUMMARY: Genetic improvements in feed efficiency (FE) and related traits could considerably reduce pig production costs and energy consumption. Thus, we performed a genetic parameter estimation and genome-wide association study of four FE and FE-related traits, namely, average daily feed intake, average daily gain, the feed conversion ratio, and residual feed intake, of two pig breeds, Yorkshire and Duroc. The results demonstrate the genetic relationships of FE and FE-related traits with two growth traits, age and backfat thickness at 100 kg. We also identified many single-nucleotide polymorphisms (SNPs) and novel candidate genes related to these traits. In addition, we found many pathways significantly associated with FE and FE-related traits, and they are generally involved in digestive and metabolic processes. The results of this study are expected to provide a valuable reference for the genomic selection of FE and FE-related traits in pigs. ABSTRACT: Feed efficiency (FE) traits are key factors that can influence the economic benefits of pig production. However, little is known about the genetic architecture of FE and FE-related traits. This study aimed to identify SNPs and candidate genes associated with FE and FE-related traits, namely, average daily feed intake (ADFI), average daily gain (ADG), the feed conversion ratio (FCR), and residual feed intake (RFI). The phenotypes of 5823 boars with genotyped data (50 K BeadChip) from 1365 boars from a nucleus farm were used to perform a genome-wide association study (GWAS) of two breeds, Duroc and Yorkshire. Moreover, we performed a genetic parameter estimation for four FE and FE-related traits. The heritabilities of the FE and FE-related traits ranged from 0.13 to 0.36, and there were significant genetic correlations (−0.69 to 0.52) of the FE and FE-related traits with two growth traits (age at 100 kg and backfat thickness at 100 kg). A total of 61 significant SNPs located on eight different chromosomes associated with the four FE and FE-related traits were identified. We further identified four regions associated with FE and FE-related traits that have not been previously reported, and they may be potential novel QTLs for FE. Considering their biological functions, we finally identified 35 candidate genes relevant for FE and FE-related traits, such as the widely reported MC4R and INSR genes. A gene enrichment analysis showed that FE and FE-related traits were highly enriched in the biosynthesis, digestion, and metabolism of biomolecules. This study deepens our understanding of the genetic mechanisms of FE in pigs and provides valuable information for using marker-assisted selection in pigs to improve FE.